ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2026
Preoperative plasma glial fibrillary acidic protein and postoperative delirium in older adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- CCL2 and CXCL2 are markers of delirium vulnerability in community dwelling older people.Age and ageing · 2026Article
- Extracellular vesicle signalling in perioperative neurocognitive disorders.Frontiers in immunology · 2026Review
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Authors and funding
14 authors.
Funding
Abstract
backgroundDelirium is a common complication of hospitalization with poor outcomes, but its underlying pathophysiology is poorly understood. We investigated the association of preoperative glial fibrillary acidic protein (GFAP), a biomarker of reactive astrocytosis, with delirium incidence and severity.
methodsData were obtained from the ongoing prospective successful aging after elective surgery (SAGES) study. GFAP was measured in preoperative plasma (n = 529). Postoperative delirium incidence and severity were measured using the confusion assessment method (CAM) and CAM-S (0-19, 19 worst), respectively. A multivariable generalized linear model (GLM) with log link and binary or Poisson error distribution was used to estimate the relative risk of delirium by GFAP quartile scale, and GLM with identity link was used to examine the association of preoperative GFAP and delirium severity.
resultsOverall mean preoperative GFAP value was 289.6 ± 153.3 pg/mL; mean value by quartile (Q) was 148.1 ± 28.6 pg/mL for Q1, 220.5 ± 19.8 pg/mL for Q2, 298.2 ± 28.4 pg/mL for Q3, and 503.4 ± 128.3 pg/mL for Q4. Delirium incidence by GFAP level was 16% in Q1, 24% in Q2, 25% in Q3, and 28% in Q4 (Cochran trend test P-value = 0.031; adjusted P-value = 0.205). Higher GFAP levels (fourth vs. first quartile) were associated with greater risk of incident delirium (adjusted relative risk 1.70, 95% confidence interval [CI]: 1.01-2.86) and greater delirium severity (adjusted mean difference 0.86, 95% CI: 0.004-1.71).
conclusionsHigh preoperative plasma GFAP was associated with increased delirium incidence and severity, suggesting GFAP may serve as a risk marker for delirium. Brain vulnerability in the setting of astrocytosis may contribute to delirium pathophysiology.
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