Evidence map›Paper›PMID 41581071›Full record

ArticleEuropean journal of immunology2026

IgD-Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid-Induced Cell Death.

Kais Almohammad, Marc Young, Sabine Vettorazzi, Franziska Greulich, Mahmoud Alkhatib, Jan Tuckermann, Hassan Jumaa, Corinna S Setz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kais AlmohammadInstitute of Immunology, Ulm University Medical Center, Albert-Einstein-Allee 11, Ulm, Germany.
Marc YoungInstitute of Immunology, Ulm University Medical Center, Albert-Einstein-Allee 11, Ulm, Germany.
Sabine VettorazziInstitute of Comparative Molecular Endocrinology and Physiology, Ulm University, Helmholtzstr. 8/1, Ulm, Germany.
Franziska GreulichChair of Metabolic Programming, TUM School of Life Sciences, ZIEL-Institute For Food & Health, Technische Universität München, Gregor-Mendel-Str. 2, Freising, Germany.
Mahmoud AlkhatibInstitute of Immunology, Ulm University Medical Center, Albert-Einstein-Allee 11, Ulm, Germany.
Jan TuckermannInstitute of Comparative Molecular Endocrinology and Physiology, Ulm University, Helmholtzstr. 8/1, Ulm, Germany.
Hassan JumaaInstitute of Immunology, Ulm University Medical Center, Albert-Einstein-Allee 11, Ulm, Germany.
Corinna S SetzInstitute of Immunology, Ulm University Medical Center, Albert-Einstein-Allee 11, Ulm, Germany.

Funding

CRC1279 : "Exploiting the Human Peptidome for Novel Antimicrobial and Anticancer Agents" to H.J. B03Further project funding by the DFG was granted to S.V. and F.G. 497680553H.J. 326914434J.T. 450627322J.T. 505870049SFB1506: "Aging at Interfaces" to H.J. and J.T. B05SFB1506: "Aging at Interfaces" to H.J. and J.T. C05S.V. 537908488
6 · The paper itself

Abstract

Glucocorticoids (GCs) regulate diverse physiological processes, comprising metabolism, immune responses, stress adaptation, and inflammation. Synthetic GCs are widely used for their powerful anti-inflammatory and immunosuppressive effects, in the treatment of autoimmune diseases, allergies, and inflammation. Here, we investigated the role of the glucocorticoid receptor (GR) in B cell development and survival using both B cell-specific GR-deficient mice and continuous in vivo GR agonist treatments. Deletion of the GR in B cells altered splenic B cell subpopulations, increasing follicular and CD21

Indexed as

B-LymphocytesGlucocorticoidsImmunoglobulin DReceptors, GlucocorticoidAnimalsApoptosisCell DeathCell DifferentiationCell SurvivalDexamethasoneImmunoglobulin MInterleukin-10Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutDexamethasoneGlucocorticoidsImmunoglobulin DImmunoglobulin MInterleukin-10PrednisoloneReceptors, GlucocorticoidB cellsglucocorticoidsIgDIgMterminal differentiation

Identifiers

PMID41581071
PMCPMC12832068

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.