ArticleIndian journal of ophthalmology2026
Regulation of immunological equilibrium by IL-6/STAT3 in glaucomatous irises and its effect on filtering bleb success.
Article in Indian journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo investigate the expression of interleukin-6 (IL-6) and its associated downstream genes within iris tissues of primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG), and secondary glaucoma (neovascular, traumatic, and uveitic) subjects, assess cytokines correlation and their influence on trabeculectomy success.
methodsThis prospective single-center study analyzed IL-6 and its downstream signaling molecules expression levels by real-time polymerase chain reaction (RT-PCR) that consisted of 25 glaucoma eyes (POAG: 10, PACG: 8, secondary glaucoma: 7) and nine eyes from the corneoscleral rims that served as controls. Correlation matrices assessed the association between these factors and trabeculectomy outcomes.
resultsCompared to controls, a significant downregulation of IL-6 expression (Control vs. POAG P = 0.004, Control vs. PACG P = 0.002); IL-6R (Control vs. POAG P = 0.0002, Control vs. PACG P = 0.012); gp130 (Control vs. POAG P = 0.003) was observed in primary glaucoma. Also, differential expression of apoptosis markers BAX (Control vs. POAG P = 0.043); BCL-2 (Control vs. POAG P = 0.002, Control vs. PACG P = 0.007), and fibrotic markers α-SMA (Control vs. POAG P = 0.01, Control vs. PACG P = 0.04) was observed. Similar cytokine expressions were observed in secondary glaucoma compared to the controls. The overall success rate of trabeculectomy was 94.11% at three months postoperatively. A significant correlation was found between IL-6R and its downstream targets.
conclusionThese findings suggested that in glaucomatous irises, altered IL-6/STAT3 signaling indicates a balance between pro- and anti-inflammatory factors, potentially explaining trabeculectomy's early effectiveness via this immunological balance.
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