Evidence map›Paper›PMID 41580978›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure.

Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian-Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao-Wei Lu, Hong Chen, Chenxi Ma and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Bo ZhuDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-2439-0026
Muhammad AminuImaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Pingjun ChenInstitute for Data Science in Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Jian-Rong LiDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Chuanpeng DongDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Chenyang LiDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Yanhua TianDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Shao-Wei LuDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Hong ChenDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Chenxi MaDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Xin HuDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Jie YeDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Andrew Y LiuDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Beibei HuangDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Frank R RojasTranslational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Parra Cuentas Edwin RogerTranslational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Ou ShiTranslational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Monique B NilssonDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Alissa PoteeteDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Khaja B KhanTranslational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Wei LuTranslational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Luisa M Solis SotoTranslational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Junya FujimotoClinical Research Center in Hiroshima, Hiroshima University Hospital, Hiroshima, Japan.
Cara HaymakerTranslational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Ignacio I WistubaTranslational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Zhubo WeiDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Linghua WangGenomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Don L GibbonsDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Ken ChenDepartment of Bioinformatics & Comp Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Alexandre ReubenDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Jason M SchenkelTranslational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
John V HeymachDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Chao ChengDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Jia WuImaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Jianjun ZhangDepartments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Funding

AACR-Johnson & Johnson Lung Cancer Innovation Science 18-90-52-ZHANNCI NIH HHS R01CA234629-01Strategic Initiative Development (STRIDE) program
6 · The paper itself

Abstract

Tumor evolution involves genetic, transcriptional, and phenotypic alterations that shape cancer cell behavior and interactions with the microenvironment. While single-cell technologies have advanced our understanding of this process, spatial dynamics remain incompletely characterized. Here, whole-exome sequencing (WES), imaging mass cytometry (IMC), and spatial transcriptomics (ST) were integrated to study molecular evolution and immune responses in two lung adenocarcinoma (LUAD) mouse models: a genetically engineered model (129S4/Sv-Kras

Indexed as

Adenocarcinoma of LungCarcinogensLung NeoplasmsPrecancerous ConditionsAnimalsDisease Models, AnimalExome SequencingHumansMiceSpatial TranscriptomicsTumor MicroenvironmentCarcinogensimaging mass cytometryspatial single cellspatial transcriptomicswhole‐exome sequencing

Identifiers

PMID41580978
PMCPMC13042775

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.