Evidence map›Paper›PMID 41580975›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

In Situ Synthesis of a Tumor Microenvironment-Activated Radiosensitizing Cu

Kang Zhu, Qiaoqiao Wei, Ying Wu, Qingqing Li, Luntao Liu, Chunxiang Mo, Chuqiao Liu, Lichao Su, Jibin Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kang ZhuState Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, P. R. China.
Qiaoqiao WeiState Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, P. R. China.
Ying WuState Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, P. R. China.
Qingqing LiCollege of Chemistry, Fuzhou University, Fuzhou, P. R. China.
Luntao LiuCollege of Chemistry, Fuzhou University, Fuzhou, P. R. China.
Chunxiang MoState Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, P. R. China.
Chuqiao LiuState Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, P. R. China.
Lichao SuCollege of Chemistry, Fuzhou University, Fuzhou, P. R. China.
Jibin SongState Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, P. R. China.ORCID https://orcid.org/0000-0003-4771-5006

Funding

Beijing Outstanding Young Scientist Program JWZQ20240101010Fundamental Research Funds for the Central Universities buctrc202235Fundamental Research Funds for the Central Universities PT2508Fundamental Research Funds for the Central Universities PT2516Fundamental Research Funds for the Central Universities ZY2503National key research and development plan 2023YFB3810002National Natural Science Foundation of China 82202239National Natural Science Foundation of China 82373101National Natural Science Foundation of China U21A20377National Natural Science Foundation of China U22A20348National Natural Science Foundation of China U24A20731
6 · The paper itself

Abstract

The efficient delivery of theranostic nanoprobes to tumor sites remains a major challenge, often hindering precise tumor imaging and effective treatment. In this study, we present a novel strategy for the in situ generation of imaging and radiosensitizing nanoprobes inside tumors, enabling responsive photoacoustic imaging and targeted radiotherapy. The designed organic-inorganic hybrid nanoprobe is composed of a copper-based layered double hydroxide (Cu-LDH) intercalated with the near-infrared organic dye IR-806, serving as a photoacoustic imaging agent (designated as CAL-IR). Upon exposure to hydrogen sulfide (H

Indexed as

Colorectal NeoplasmsCopperPhotoacoustic TechniquesRadiation-Sensitizing AgentsRadiotherapy, Image-GuidedTumor MicroenvironmentAnimalsCell Line, TumorHumansMiceCopperRadiation-Sensitizing Agentsphotoacoustic imagingradiotherapyresponsive bioimagingX‐ray

Identifiers

PMID41580975
PMCPMC13045243

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.