Building Molecules by a Self-Replicator That Catalyzes Acyl Hydrazone Formation.

Kayleigh S van Esterik, Tommaso Marchetti, Sijbren Otto

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kayleigh S van EsterikCentre for Systems Chemistry, Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 3, 9747 AG, Groningen, the Netherlands.ORCID https://orcid.org/0000-0002-4614-0805

Tommaso MarchettiCentre for Systems Chemistry, Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 3, 9747 AG, Groningen, the Netherlands.

Sijbren OttoCentre for Systems Chemistry, Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 3, 9747 AG, Groningen, the Netherlands.ORCID https://orcid.org/0000-0003-0259-5637

Funding

Dutch Ministry of Education, Culture and Science 024.001.035European Research Council 101118938Wellcome Trust 203597

6 · The paper itself

Abstract

Catalysis of bond-forming reactions is key to the development of life-like chemical systems as it allows to build up new material, increasing molecular complexity and diversity. Integrating catalysis with other characteristic properties of life, like self-replication, represents an important advance in the transition from chemistry to life. We have previously shown that catalysis can emerge in synthetic self-replicators that form through supramolecular assembly. However, the organocatalyzed reactions were solely bond-breaking so far. We now report the successful expansion of the catalytic promiscuity of these systems to bond-forming reactions. We show that a self-replicator efficiently catalyzes acyl hydrazone formation between different hydrazides and aldehydes. This marks an important step towards the further development of evolvable systems that combine metabolic activity with self-replication.

Indexed as

Acyl hydrazone formationDe‐novo lifeSelf‐replicationSupramolecular catalysisSystems chemistry

Identifiers

PMID41580903

DOI10.1002/anie.202506986

PMCPMC12955535

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.