Evidence map›Paper›PMID 41580847›Full record

ArticleClinical epigenetics2026

Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson's disease.

Anna E Goodheart, Chi-Hyeon Yoo, Aline Fassini, Tewodros M Dagnew, Rong Ye, Robin Striar, Moqing Quan, Anna K Rattray, Tyler N Meyer, Erin Peterec and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Anna E GoodheartHarvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
Chi-Hyeon YooDepartment of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Aline FassiniDepartment of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Tewodros M DagnewDepartment of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Rong YeHarvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
Robin StriarDepartment of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Moqing QuanDepartment of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Anna K RattrayDepartment of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Tyler N MeyerDepartment of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Erin PeterecDepartment of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Han LeeDepartment of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Stephanie A FiedlerDepartment of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Jacob M HookerHarvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
Hsiao-Ying WeyHarvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
Changning WangHarvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
Stephen N GompertsHarvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA. gomperts.stephen@mgh.harvard.edu.

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
Imaging epigenetic dysregulation in the Lewy body dementias with [11C]MartinostatR01AG082331 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Stephen N. Gomperts, Changning Wang · 2023 to 2026
$3.3M
Imaging Epigenetic Mechanisms in the Lewy Body Dementias with [11C]MartinostatR56AG070827 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GOMPERTS, STEPHEN N., WANG, CHANGNING · 2021 to 2021
$776k
Imaging Epigenetic Mechanisms in Parkinson's Disease with [11C]MartinostatR21NS109833 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GOMPERTS, STEPHEN N., WANG, CHANGNING · 2018 to 2019
$463k
NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG082331NIA NIH HHS R56 AG070827NINDS NIH HHS R21 NS109833
6 · The paper itself

Abstract

backgroundHistone deacetylases (HDACs) are epigenetic molecules responsible for regulation of gene transcription. Dysregulation of HDACs has been linked to neurodegenerative disease. Here, we used the class I HDAC PET radioligand [

resultsCompared to HC, [

conclusionsThe findings of this exploratory study reveal elevated levels of class I HDACs in motor cortex in PD and bidirectional changes in their regional density in the Lewy body dementias.

Indexed as

BrainHistone DeacetylasesLewy Body DiseaseParkinson DiseaseAdamantaneAgedCarbon RadioisotopesCross-Sectional StudiesFemaleHumansHydroxamic AcidsMaleMiddle AgedPositron-Emission TomographyAdamantaneCarbon RadioisotopesHistone DeacetylasesHydroxamic AcidsmartinostatDementia with Lewy bodiesHistone deacetylaseLewy body dementiaMartinostatParkinson’s disease

Identifiers

PMID41580847
PMCPMC12911031

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.