Evidence map›Paper›PMID 41580740›Full record

ArticleArthritis research & therapy2026

Dysregulation of YTHDF2 promotes the over expression of interferon beta in anti-MDA5 antibody-positive dermatomyositis.

Mengxiao Zhang, Qishun Geng, Xing Wang, Xiaoxue Cao, Sang Lin, Qiwen Jin, Yi Jiao, Qinglin Peng, Cheng Xiao

Abstract read
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In one paragraph

Article in Arthritis research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Mengxiao ZhangInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China.
Qishun GengInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China.
Xing WangInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China.
Xiaoxue CaoInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China.
Sang LinGraduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, 100029, China.
Qiwen JinDepartment of Rheumatology, Key Lab of Myositis, China-Japan Friendship Hospital, Beijing, 100029, China.
Yi JiaoInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China.
Qinglin PengDepartment of Rheumatology, Key Lab of Myositis, China-Japan Friendship Hospital, Beijing, 100029, China. pqinglin@163.com.
Cheng XiaoInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China. xc2002812@126.com.

Funding

The National Natural Science Foundation of China 82572056, 82171788, 82371810
6 · The paper itself

Abstract

backgroundDysregulation of N6-methyladenosine (m6A) has been implicated in the pathophysiology of various autoimmune diseases. However, its role in dermatomyositis (DM), particularly in cases associated with anti-MDA5 antibodies, remains unclear. This study aimed to elucidate the potential involvement of m6A modifications of mRNAs in the pathogenesis of anti-MDA5

methodsWe assessed mRNA m6A methylation levels in peripheral blood mononuclear cells (PBMCs) from anti-MDA5

resultsThe overall level of mRNA m6A methylation was found to be decreased in PBMCs of anti-MDA5

conclusionsOur findings suggest a decrease in YTHDF2 expression in anti-MDA5

Indexed as

AutoantibodiesDermatomyositisInterferon-betaInterferon-Induced Helicase, IFIH1RNA-Binding ProteinsAdultFemaleHumansLeukocytes, MononuclearMaleMiddle AgedRNA, MessengerSignal TransductionTHP-1 CellsAutoantibodiesIFIH1 protein, humanInterferon-betaInterferon-Induced Helicase, IFIH1RNA-Binding ProteinsRNA, MessengerYTHDF2 protein, humanAnti-MDA5+DMIFNBJAK inhibitorsYTHDF2

Identifiers

PMID41580740
PMCPMC12911376

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.