Observational studyBMC oral health2026
Temporomandibular disorder in children with juvenile idiopathic arthritis with and without temporomandibular joint involvement compared to controls - a two-year prospective multicenter cohort study.
Observational study in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03904459 (The Norwegian JIA Study - Temporo-mandibular Involvement, Oral Health, Uveitis, Bone Health and Quality of Life in Children With Juvenile Idiopathic Arthritis), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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The Norwegian JIA Study - Temporo-mandibular Involvement, Oral Health, Uveitis, Bone Health and Quality of Life in Children With Juvenile Idiopathic Arthritis (JIA). A Large Multicentre Study
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Authors and funding
20 authors.
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Abstract
objectivesThis study compares the prevalence of orofacial signs and symptoms of temporomandibular disorder (TMD) in children with juvenile idiopathic arthritis (JIA) and controls at two study visits two years apart. We also examine the prevalence of TMD diagnoses and their association with general disease activity in children with JIA.
methodsIn the NorJIA cohort study, children with JIA aged 4 to 16 years were recruited consecutively from three pediatric rheumatology clinics in Norway and together with an age- and sex-matched non-JIA control group from public dental health service clinics. Children with JIA were classified into temporomandibular joint (TMJ) involvement and no TMJ involvement groups on the basis of magnetic resonance imaging findings. An adapted version of the Diagnostic Criteria for TMD protocol was applied to assess myalgia, arthralgia, headache attributed to TMD, and disc displacement in all children at both visits.
resultsFifty-five children with JIA and TMJ involvement, 132 with JIA without TMJ involvement, and 189 controls completed TMD examinations at both visits. At Visit I, at least one TMD diagnosis was present in 49% of the children with JIA and TMJ involvement, 19% with JIA without TMJ involvement, and 5% of the controls; after two years, these frequencies were 38%, 16%, and 7%, respectively. Children with active JIA disease at baseline had a higher risk of orofacial myalgia (OR 10.5, 95% CI 3.1–36.4).
conclusionsTMD was more common in children with JIA than in non-JIA controls. Active JIA disease increased the risk of temporomandibular myalgia, regardless of TMJ involvement. Pediatric rheumatologists and dentists should regularly monitor the orofacial region in all children with JIA.
trial registrationRegistered retrospectively on clinicaltrials.gov (NCT03904459, 03/04/2019).
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