ArticleCardiovascular diabetology2026
Association between the combined c-reactive protein-triglyceride glucose index and hypertension with long-term stroke among cardiovascular-kidney-metabolic syndrome stages 0-3 population: a nationwide prospective cohort study.
Article in Cardiovascular diabetology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Associations between the C-reactive protein-triglyceride-glucose index and its derived indices and the incidence and progression of cardiometabolic multimorbidity in participants with metabolic dysfunction-associated steatotic liver disease: a large-scale prospective cohort study.Cardiovascular diabetology · 2026Article
- Associations of the combined C-reactive protein-triglyceride glucose index and frailty index in different dimensions with incident stroke among individuals with stages 0-3 cardiovascular-kidney-metabolic syndrome.Cardiovascular diabetology · 2026Article
- Synergistic effects of insulin resistance and revascularization completeness on prognosis in patients with coronary artery calcification.Cardiovascular diabetology · 2026Observational
- Associations of eight insulin resistance-related indices and genetic risk with incident cardiometabolic multimorbidity among participants with hypertension: a large prospective cohort study.Cardiovascular diabetology · 2026Observational
- Lipid accumulation product and its association between new onset stroke among middle age and elderly population.BMC cardiovascular disorders · 2026Article
- Association between C-reactive protein-triglyceride-glucose index and risk of stroke in different renal function status: a national cohort study.Cardiovascular diabetology · 2026Article
- Association of the hs-CRP-TyG index with coronary artery disease risk and angiographic severity: a retrospective comparative study with the TyG index.Frontiers in endocrinology · 2026Article
- Association between the C-reactive protein-triglyceride-glucose index and coronary heart disease in metabolic dysfunction-associated steatotic liver disease patients: a cross-sectional study.Frontiers in endocrinology · 2026Article
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6 authors.
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Abstract
backgroundStroke is one of the advanced outcomes of cardiovascular kidney metabolic syndrome (CKM). The combined effects of inflammation, insulin resistance, and hypertension in stroke remain to be fully elucidated in population studies. This study investigates the association between the composite TyG inflammation index (c-reactive protein-triglyceride glucose index, CTI) and hypertension with long-term stroke.
methodsThis longitudinal cohort study included 9082 participants from the China Health and Retirement Longitudinal Study (CHARLS). The associations with stroke risk were assessed using Cox proportional hazards models and Kaplan-Meier analysis, while predictive performance was evaluated using ROC curves and time-dependent AUC. The contribution of each component was determined by Weighted Quantile Sum (WQS) regression. Subgroup analysis and sensitivity analysis were also conducted.
resultsOver a median 9-year follow-up, 811 (8.9%) incident stroke cases occurred. A significant dose-response relationship was observed, with the highest CTI-hypertension group exhibiting a fully adjusted hazard ratio of 3.19 (95% CI 2.62-3.88) for stroke compared to the lowest group. The combined CTI-hypertension model demonstrated superior predictive performance (AUC = 0.672) versus hypertension-alone (AUC = 0.661) or CTI-alone (AUC = 0.651) models. WQS analysis identified C-reactive protein (38.8%) and hypertension (31.7%) as the predominant risk factors.
conclusionIntegrating CTI with hypertension significantly improves stroke risk stratification in CKM stage 0-3 populations, supporting its potential for early identification of high-risk individuals.
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