Evidence map›Paper›PMID 41580668›Full record

ArticleBMC ophthalmology2026

Clinical characteristics and surgical outcomes of full-thickness macular hole secondary to retinal vein occlusion.

Xijin Wu, Xiaohan Yang, Biying Qi, Yanping Yu, Xinbo Wang, Qinlang Jia, Xiao Feng, Wu Liu

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Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Xijin WuBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.
Xiaohan YangBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.
Biying QiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.
Yanping YuBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.
Xinbo WangBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.
Qinlang JiaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.
Xiao FengBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.
Wu LiuBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang, Dongcheng District, Beijing, 100730, China. trliuwu@ccmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the clinical characteristics and visual and anatomical surgical prognosis for full-thickness macular hole (FTMH) secondary to retinal vein occlusion (RVO).

methodThis retrospective study reviewed 13 eyes from 13 consecutive patients with FTMH after RVO who underwent pars plana vitrectomy (PPV) combined internal limiting membrane (ILM) peeling or ILM flap insertion. Clinical demographics and spectral-domain optical coherence tomography (SD-OCT) features were evaluated. Multiple linear regression was used to analyze the associated factors for the final best-corrected visual acuity (BCVA).

resultsOf the 13 eyes, 11 had a previous branch RVO (BRVO) and 2 had a central RVO (CRVO). The mean minimum linear diameter (MLD) of these secondary macular holes was 469.31 ± 197.96 μm. Eight subjects (61.5%) showed a FTMH secondary to a long-standing RVO (RVO episode longer than 6 months), and the rest 5 subjects (38.5%) developed a FTMH after a recent onset RVO within 6 months. The two groups shared similar baseline BCVA (P = 0.414), MLD (P = 0.218), and BD (P = 0.453). The mean follow-up period was 10.0 months. All cases showed anatomical closure at the last follow-up, with BCVA significantly improved from 0.90 ± 0.28 logMAR at baseline to 0.45 ± 0.34 logMAR after surgery (P<0.001). The final BCVA of the eyes after recent onset RVO was better than the ones after long-standing RVO (P = 0.012). Regression analysis showed that the final BCVA was significantly associated with the baseline BCVA, RVO duration, and the ellipsoid zone (EZ) integrity (P<0.001).

conclusionFTMH secondary to RVO could achieve favorable anatomical and visual acuity success with PPV. The cases secondary to a recent RVO might have a better visual prognosis. The initial BCVA and postoperative EZ recovery were associated with the final BCVA.

Indexed as

Retinal PerforationsRetinal Vein OcclusionVisual AcuityVitrectomyAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesTomography, Optical CoherenceTreatment OutcomePars plana vitrectomyRetinal vein occlusionSecondary full-thickness macular holeVisual acuity

Identifiers

PMID41580668
PMCPMC12910922

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.