ArticleBMC complementary medicine and therapies2026
Efficacy of Ayurveda interventions (Pushkar Guggulu and Haritaki) as an adjunct to standard care in stable coronary artery disease: study protocol for a double-blind, randomized controlled study.
Article in BMC complementary medicine and therapies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundCoronary artery disease (CAD) is a substantial contributor to cardiovascular-related morbidity and mortality worldwide. Contemporary medications for CAD management need to be administered for longer periods with limited success. In addition, these medications have limitations owing to their adverse effects on long-term use. Therefore, it is imperative to identify safe, effective, and economical therapeutic options to lower the risk of CAD-related morbidity, mortality, and recurrence. This protocol was developed to assess the clinical efficacy and safety of Ayurveda interventions, Pushkar Guggulu and Haritaki, as an adjunct to standard care in individuals diagnosed with stable CAD compared with standard care alone.
methodsThis randomized controlled trial (RCT) employs a double-blind, randomized controlled design and will be conducted at the Department of Cardiology, Safdarjung Hospital, New Delhi, India. A total of 100 individuals of any gender aged 40-70 years and diagnosed with stable CAD will be enrolled in the study. The participants will be randomly assigned in a 1:1 ratio to receive either Ayurveda interventions (Pushkar Guggulu capsules 1 gram, and Haritaki capsules 500 mg twice daily after meals) or the matching placebo of both the aforementioned Ayurveda interventions for 180 days. The conventional standard care per the current American College of Cardiology/American Heart Association guidelines for CAD management will be provided in both groups. The primary outcome is the change in the Seattle Angina Questionnaire (SAQ) score from baseline. The secondary outcome measures include the change in the grade of the Canadian Cardiovascular Society grading scale of angina pectoris; the change in the grade of the exercise stress test from baseline; the change in lipid profile, IL-6, and serum pro-BNP levels from baseline; the change in the need for standard care medications for CAD from baseline; and the change in health-related QoL (assessed by the SF-12 questionnaire). Safety will be evaluated by recording the incidence of adverse events and changes in laboratory safety parameters (CBC, LFT, KFT) from baseline. DISCUSSION: The outcomes of this RCT can be utilized to develop a strategy to integrate Ayurveda interventions with conventional standard management to achieve a better prognosis in CAD patients.
trial registrationThe study is prospectively registered with the Clinical Trial Registry of India (CTRI/2024/02/062553 dated February 12, 2024).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.