Evidence map›Paper›PMID 41580633›Full record

ArticleBMC ophthalmology2026

Analysis of factors associated with axial length development in patients with unilateral congenital cataract.

Jianling Yang, Xin Zhong, Yi Shi, Lichun Wu, Yuqing Wu, Geng Wang

Abstract read
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Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jianling YangDepartment of Cataract, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, 515041, China.
Xin ZhongDepartment of Cataract, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, 515041, China.
Yi ShiDepartment of Cataract, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, 515041, China.
Lichun WuDepartment of Cataract, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, 515041, China.
Yuqing WuDepartment of Cataract, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, 515041, China.
Geng WangDepartment of Cataract, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, 515041, China. wg@jsiec.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the factors associated with axial length (AL) development in patients with unilateral congenital cataract.

methodsThis retrospective study reviewed clinical records of children with unilateral congenital cataract who underwent surgery at the Joint Shantou International Eye Center from October 2014 to October 2019. Multiple linear regression analysis was utilized to assess the impact of different factors on axial length differences (ALD). Statistical analysis was performed using SPSS software version 29.

resultsA total of 81 patients were included, aged 5.5 months to 14 years (mean 4.86 ± 3.54 years), including 45 females and 36 males. The AL was significantly longer in affected eyes across all groups (p = 0.003; p < 0.001; p = 0.015; p < 0.001, respectively). A positive correlation between ALD and duration of form deprivation was observed in the 0-1year group (r = 0.679, p = 0.031)), whereas a negative correlation was found in the combined age groups of 1–14 years (r=-0.322, p = 0.006). Multiple linear regression analysis revealed that duration of form deprivation (β =-0.307, p = 0.015, 95%CI: [-0.187, -0.021]), degree of lens opacity (β = 0.374, p = 0.041, 95%CI: [0.042, 1.855]), and history of oxygen exposure (β = -0.315, p = 0.025, 95%CI: [-1.843, -0.125]) were significantly associated with ALD.

conclusionThe AL was significantly longer in affected eyes across all groups. The duration of form deprivation, degree of lens opacity, and history of oxygen exposure collectively contribute to ALD. Early detection and intervention are crucial to prevent abnormal ocular development in children with congenital cataract.

Indexed as

Axial Length, EyeCataractAdolescentCataract ExtractionChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesVisual AcuityAxial lengthCongenital cataractForm-deprivationOcular development

Identifiers

PMID41580633
PMCPMC12911401

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