Evidence map›Paper›PMID 41580553›Full record

ArticleSpine deformity2026

Leave it alone: the natural history of growth-friendly graduates without a final fusion.

Rayyan Abid, Bryan O Ren, Robert F Murphy, Jeffrey R Sawyer, John M Flynn, John B Emans, John T Smith, Paul D Sponseller, Norman Ramirez, Christina K Hardesty and 1 more

Abstract readMulticenter Study
In one paragraph

Article in Spine deformity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rayyan AbidDepartment of Orthopaedic Surgery, University Hospitals Rainbow Babies and Children's, 2101 Adelbert Rd, Cleveland, OH, 44106, USA.
Bryan O RenDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.
Robert F MurphyMedical University of South Carolina/Charleston VA, Charleston, SC, USA.
Jeffrey R SawyerCampbell Clinic Orthopaedics, Memphis, TN, USA.
John M FlynnThe Children's Hospital of Philadelphia, Philadelphia, PA, USA.
John B EmansBoston Children's Hospital, Boston, MA, USA.
John T SmithPrimary Children's Hospital, Salt Lake City, UT, USA.
Paul D SponsellerJohns Hopkins University, Baltimore, MD, USA.
Norman RamirezLa Concepcion Hospital, San German, PR, USA.
Christina K HardestyDepartment of Orthopaedic Surgery, University Hospitals Rainbow Babies and Children's, 2101 Adelbert Rd, Cleveland, OH, 44106, USA. Christina.Hardesty@UHhsopitals.org.ORCID http://orcid.org/0000-0002-8643-6889
Pediatric Spine Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe natural history of growth-friendly graduates treated with growing instrumentation but no final fusion is unknown. Two previous reports exist with one analyzing 30 growin g rod patients with no definitive fusion and another including 10 patients with growing rod removal, but no comprehensive data exist in the literature.

methodsA multi-center database was queried for patients treated with TGR or VEPTR and at least 2 years of follow-up from their index procedure. Patients met inclusion criteria if they had not undergone a final fusion procedure but had completed planned interventions for early onset scoliosis and had sufficient follow-up. Kaplan-Meier analysis was performed to model rates of UPROR and complications in patients with retained and removed implants over time.

resultsOf 233 included patients, definitive treatment was implant maintenance in 203 (87%) and removal in 30 (13%). Patients with retained implants experienced 10 (5%) UPRORs and 41 (20%) complications after final lengthening. Patients with removed implants had 0 UPRORs and 10 (33%) complications after implant removal. Patients with available pre-definitive and follow-up measurements and whose implants were removed increased by a mean 14.3° of coronal curvature compared to 19.0° in those who retained implants at mean 3.8 and 3.7 year follow-up, respectively.

conclusionGrowth-friendly graduates without final fusion demonstrate low rates of UPROR and complications following definitive lengthening or implant removal. However, those who undergo implant removal are more likely to experience complications. Coronal curve magnitude was moderately maintained in both cohorts, suggesting that avoidance of definitive fusion may be viable for some patients.

Indexed as

ScoliosisSpinal FusionAdolescentChildFemaleFollow-Up StudiesHardware RemovalHumansMalePostoperative ComplicationsRetrospective StudiesComplicationsEarly onset scoliosisGraduateImplantsUPROR

Identifiers

PMID41580553
PMCPMC13282303

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