Evidence map›Paper›PMID 41580530›Full record

ArticleCell death and differentiation2026

CARM1-mediated hypoxanthine-enriched exosomes rewire inosine metabolism and impair CD8

Jilong Yin, Zhipeng Su, Xi Hu, Haojie Sun, Zenghui Sun, Shuyu Zhou, Wenwen Xu, Ying Xi, Lanlan Liu, Jinwei Zhang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jilong Yin *Advanced Medical Research Institute, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Zhipeng Su *Advanced Medical Research Institute, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Xi HuAdvanced Medical Research Institute, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Haojie SunAdvanced Medical Research Institute, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Zenghui SunAdvanced Medical Research Institute, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Shuyu ZhouAdvanced Medical Research Institute, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Wenwen XuAdvanced Medical Research Institute, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Ying XiAdvanced Medical Research Institute, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Lanlan LiuAdvanced Medical Research Institute, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Jinwei ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Qian ZhaoDepartment of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Yi QiaoAdvanced Medical Research Institute, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Jian ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.ORCID 0000-0001-5106-1397
Yingjie ZhangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Ying XuDepartment of thyroid and breast surgery, Shandong Provincial Third Hospital, Shandong University, Jinan, Shandong, China. xuying2205@126.com.ORCID 0000-0002-8941-7560
Yuchen FanDepartment of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, China. fanyuchen@sdu.edu.cn.ORCID 0000-0002-9126-679X
Xiaona YouState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. youxiaona123@sdu.edu.cn.ORCID 0000-0001-9996-1466
Xiangbo MengAdvanced Medical Research Institute, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. xbmeng@sdu.edu.cn.ORCID 0009-0008-9067-5445
Fabao LiuAdvanced Medical Research Institute, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. liufabao@sdu.edu.cn.ORCID 0000-0003-0019-7301

Funding

National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 82173135National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 82472864
6 · The paper itself

Abstract

Cancer cells utilize tumor-derived exosomes to suppress antitumor immunity. Herein, we identify co-activator-associated arginine methyltransferase 1 (CARM1) as a key regulator of exosome biogenesis and metabolite sorting that inhibiting CD8

Indexed as

CD8-Positive T-LymphocytesExosomesInosineProtein-Arginine N-MethyltransferasesAnimalsCell Line, TumorFemaleHumansMiceT-Cell ExhaustionInosineProtein-Arginine N-Methyltransferases

Identifiers

PMID41580530
PMCPMC13434425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.