ArticleIntensive care medicine experimental2026
Perioperative micro-arterial function and extravasation in cytoreductive ovarian cancer surgery: an observational study.
Article in Intensive care medicine experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01311297 (Clinical Monitoring of Endothelial Dysfunction for Pregnant Women and in the Perioperative Course - a Pilot Study), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Monitoring of Endothelial Dysfunction for Pregnant Women and in the Perioperative Course - a Pilot Study
Who cites it
2 citing papers in PubMed.
- Altered ANG/TIE gene expression in advanced ovarian cancer is not accompanied by disproportionate body water accumulation relative to perioperative fluid balance.Scientific reports · 2026Article
- Correction: Perioperative micro‑arterial function and extravasation in cytoreductive ovarian cancer surgery: an observational study.Intensive care medicine experimental · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
backgroundPatients undergoing extended multivisceral, non-cardiac surgery require a high demand for intravenous fluid administration, leading to substantial positive fluid balances. This study aimed to perioperatively characterize extravasation as a correlate of capillary leakage and micro-arterial regulation, as well as venous return characteristics, as possible causes for the positive fluid balances.
methodsIn this single center, observational trial we included patients undergoing abdominal debulking surgery due to ovarian cancer. The measurements were performed by a venous congestion plethysmography (VCP) protocol to determine extravasation, micro-arterial reagibility, and after deflation of congestion venous outflow characteristics at timepoints before and during surgery, and repeatedly during the postoperative course.
resultsThirty patients with primary ovarian cancer undergoing cytoreductive surgery treated within a goal-directed hemodynamic algorithm (GDA) based on the esophageal Doppler were included in the analysis. Stroke volume index did not change throughout the procedure with an increase in heart rate and consequently an increase in cardiac index. The norepinephrine requirements to maintain mean arterial pressure increased during surgery. Patients received a median 1750[25-quartile 1075;75-quartile 2100]ml crystalloids and 1000[1000;1500]ml starches, transfusions of 0[0;1040]ml red-packed cells, and 360[0;2880]ml fresh-frozen plasma. The intraoperative fluid and blood loss of 1020[508;1695]ml resulted in a positive fluid balance (2820[1338;6075]ml). Extravasation did not increase during surgery, even in the presence of substantially positive fluid balances. On the third and fifth postoperative days, extravasation increased relative to the preoperative baseline value. The micro-arterial function deteriorated throughout the course of the surgery, recovering to baseline values within 4 h after surgery. The venous outflow characteristics of the limb after releasing the venous congestion deteriorated over the course of surgery.
conclusionsThere was no increase in extravasation measured by VCP during surgery despite a substantial intraoperative positive fluid balance, showing that they were not associated with each other. The micro-arterial function and venous backflow characteristics deteriorated during surgery, indicating that vascular dilation rather than capillary leakage may contribute to the high fluid demands.
trial registrationClinicalTrials.gov identifier: NCT01311297.
Identifiers
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Registered trials
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