Evidence map›Paper›PMID 41580508›Full record

ReviewSkeletal radiology2026

Clinical applications of UTE-T2* in knee MRI.

Karen Y Cheng, Arya Suprana, Yajun Ma, Dina Moazamian, Saeed Jerban, Christine B Chung

Abstract readReview
In one paragraph

Review in Skeletal radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karen Y ChengDepartment of Radiology, University of California San Diego, La Jolla, San Diego, CA, USA.
Arya SupranaDepartment of Radiology, University of California San Diego, La Jolla, San Diego, CA, USA.
Yajun MaDepartment of Radiology, University of California San Diego, La Jolla, San Diego, CA, USA.
Dina MoazamianDepartment of Radiology, University of California San Diego, La Jolla, San Diego, CA, USA.
Saeed JerbanDepartment of Radiology, University of California San Diego, La Jolla, San Diego, CA, USA.
Christine B ChungDepartment of Radiology, University of California San Diego, La Jolla, San Diego, CA, USA. cbchung@health.ucsd.edu.ORCID http://orcid.org/0000-0002-0821-5458

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many of the tissues of interest in the evaluation of the knee by magnetic resonance imaging (MRI), including subchondral bone, deep calcified layer of cartilage, menisci, tendons, and ligaments, have very short transverse (T2 and T2*) relaxation times related to their intrinsic structure. These tissues appear anechoic on conventional MRI sequences as signal has already decayed to its minimum when image acquisition begins. Only in the setting of significant injury or degeneration is there detectable signal on conventional MRI sequences. Ultrashort echo time (UTE) MRI, which allows for the qualitative and quantitative assessment of short T2 tissues in their normal states, offers a unique opportunity to detect and intervene upon pathological changes early to prevent irreversible damage. Changes on UTE-T2* imaging allow for the identification of subtle alterations in collagen structure, hydration status, and mineralization of tissues that precede morphologic changes visible on conventional imaging. Early detection of such microstructural changes can allow for the earlier diagnosis of tendinopathy, meniscal injury or degeneration, and early osteoarthritis, potentially allowing for improved patient outcomes through earlier intervention. This review will focus specifically on the clinical applications of one UTE MRI technique, UTE-T2*, in the evaluation of musculoskeletal tissues about the knee.

Indexed as

Joint DiseasesKnee InjuriesKnee JointMagnetic Resonance ImagingHumansImage EnhancementKneeMRIUTE-T2*

Identifiers

PMID41580508
PMCPMC13309509

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.