Evidence map›Paper›PMID 41580401›Full record

ArticleNature communications2026

Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques.

K Marche, N Trudel, U Schüffelgen, S Smart, C M Harbison, J Scholl, J Sallet, F-X Neubert, J Algermissen, N Khalighinejad and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

K Marche *Oxford Centre for Integrative Neuroimaging (OxCIN), Department of Experimental Psychology, University of Oxford, Oxford, UK. kjl.marche@gmail.com.ORCID http://orcid.org/0000-0003-0663-5253
N Trudel *Oxford Centre for Integrative Neuroimaging (OxCIN), Department of Experimental Psychology, University of Oxford, Oxford, UK.
U SchüffelgenOxford Centre for Integrative Neuroimaging (OxCIN), Department of Experimental Psychology, University of Oxford, Oxford, UK.
S SmartOxford Centre for Integrative Neuroimaging (OxCIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
C M HarbisonOxford Centre for Integrative Neuroimaging (OxCIN), Department of Experimental Psychology, University of Oxford, Oxford, UK.
J SchollUniversité Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon (CRNL), U1028 UMR5292, Le Vinatier Psychiatrie Universitaire Lyon Métropole, Bron, France.ORCID http://orcid.org/0000-0001-9969-1355
J SalletOxford Centre for Integrative Neuroimaging (OxCIN), Department of Experimental Psychology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-7878-0209
F-X NeubertOxford Centre for Integrative Neuroimaging (OxCIN), Department of Experimental Psychology, University of Oxford, Oxford, UK.
J AlgermissenOxford Centre for Integrative Neuroimaging (OxCIN), Department of Experimental Psychology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-1694-7069
N KhalighinejadOxford Centre for Integrative Neuroimaging (OxCIN), Department of Experimental Psychology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-8515-5789
J X O'ReillyOxford Centre for Integrative Neuroimaging (OxCIN), Department of Experimental Psychology, University of Oxford, Oxford, UK.
M C Klein-FlüggeOxford Centre for Integrative Neuroimaging (OxCIN), Department of Experimental Psychology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-5156-9833
Mfs RushworthOxford Centre for Integrative Neuroimaging (OxCIN), Department of Experimental Psychology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-5578-9884

Funding

Wellcome Trust
6 · The paper itself

Abstract

Reversal tasks have been regarded as probes of behavioural inhibition and linked to prefrontal and specifically orbitofrontal cortex. The centrality of behavioural inhibition to reversal task performance and the task's dependence on particular prefrontal sub-regions have, however, been questioned in primates. Using a combination of whole brain recording, transient ultrasonic disruption, two types of reversal task, and a task model emphasizing identification of transitions between latent states, we show that male macaques track latent state transitions in addition to choice values in reversal tasks. Activity reflecting both these features is prominent in dorsomedial frontal cortex, and anterior and dorsomedial thalamus when, and just before, animals select choices. By contrast, hippocampal activity continually tracks the probability of a reversal between latent states. We identify patterns of activity interaction spanning the three nodes of this circuit and demonstrate that disruption of each leads to reversal task impairment albeit in different ways.

Indexed as

Nerve NetPrefrontal CortexReversal LearningAnimalsBehavior, AnimalChoice BehaviorHippocampusMacacaMacaca mulattaMaleNeural PathwaysThalamus

Identifiers

PMID41580401
PMCPMC12852943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.