Evidence map›Paper›PMID 41580300›Full record

ArticleScandinavian journal of immunology2026

Similar Individual Serum Levels of MCP-1, TNF-α, and IL-6 From Periodontitis Patients Before and 1 Year After Treatment.

Teun J de Vries, Sergio Bizzarro, Irene Di Ceglie, Doran Y Sol, Peter L E M van Lent, Ton Schoenmaker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scandinavian journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Teun J de VriesDepartment of Periodontology, Academic Centre for Dentistry (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-6464-5172
Sergio BizzarroDepartment of Periodontology, Academic Centre for Dentistry (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0002-5228-5998
Irene Di CeglieDepartment of Rheumatology, Radboud University, Nijmegen, the Netherlands.ORCID https://orcid.org/0000-0002-5966-2186
Doran Y SolDepartment of Periodontology, Academic Centre for Dentistry (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, the Netherlands.
Peter L E M van LentDepartment of Rheumatology, Radboud University, Nijmegen, the Netherlands.
Ton SchoenmakerDepartment of Periodontology, Academic Centre for Dentistry (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-6649-374X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of periodontitis may lower the inflammation status as measured in sera from patients. To investigate this in a biological assay, we co-cultured periodontal ligament fibroblasts (PDLFs) from a healthy donor and peripheral blood mononuclear cells (PBMCs) as a source for osteoclasts. PDLFs were primed for 3 days with serum from periodontitis patients before and from 1 year after successful treatment of periodontitis (n = 13). After priming, PBMCs were added. No significant differences in the number of osteoclasts that formed after 3 weeks were found between baseline and after-treatment serum priming. To find an explanation, we analysed the serum composition on the presence of inflammatory, pro-osteoclastogenic cytokines. We found no differences between before and after treatment for cytokines MCP-1, TNF-α, and IL-6. Interestingly, these levels of cytokines at baseline and after treatment strongly correlated per individual (correlation p-value between p = 0.03 and p < 0.0001, correlation r

Indexed as

Chemokine CCL2Interleukin-6PeriodontitisTumor Necrosis Factor-alphaAdultCells, CulturedCoculture TechniquesFemaleFibroblastsHumansLeukocytes, MononuclearMaleMiddle AgedOsteoclastsPeriodontal LigamentCCL2 protein, humanChemokine CCL2IL6 protein, humanInterleukin-6Tumor Necrosis Factor-alphacytokine equilibriumcytokine signatureIL‐6MCP‐1osteoclastperiodontal ligament fibroblastsperiodontitisserumTNF‐α

Identifiers

PMID41580300
PMCPMC12831644

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.