Deficient mitochondrial tRNA modifications arising from TRMU mutation led to the liver-specific failure.

Xiao He, Qinghai Zhang, Chao Chen, Yutao Wu, Kai Wang, Shihao Yao, Haiyan Sun, Min-Xin Guan

Abstract read

In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiao HeCenter for Mitochondrial Biomedicine and Department of General Surgery, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China; Center for Genetic Medicine, Zhejiang University International Institute of Medicine, Yiwu, Zhejiang, China.

Qinghai ZhangCenter for Mitochondrial Biomedicine and Department of General Surgery, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China; Center for Genetic Medicine, Zhejiang University International Institute of Medicine, Yiwu, Zhejiang, China.

Chao ChenCenter for Mitochondrial Biomedicine and Department of General Surgery, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China; Center for Genetic Medicine, Zhejiang University International Institute of Medicine, Yiwu, Zhejiang, China.

Yutao WuInstitute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China.

Kai WangInstitute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China.

Shihao YaoCenter for Mitochondrial Biomedicine and Department of General Surgery, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China; Center for Genetic Medicine, Zhejiang University International Institute of Medicine, Yiwu, Zhejiang, China.

Haiyan SunInstitute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China.

Min-Xin GuanCenter for Mitochondrial Biomedicine and Department of General Surgery, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China; Center for Genetic Medicine, Zhejiang University International Institute of Medicine, Yiwu, Zhejiang, China; Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorders, Hangzhou, Zhejiang, China. Electronic address: gminxin88@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Posttranscriptional nucleotide modifications of tRNAs play the critical roles in their structure and function. Deficient τm

Indexed as

Liver FailureMitochondriaMutationRNA, TransfertRNA MethyltransferasesAnimalsLiverRNA Processing, Post-TranscriptionalZebrafishRNA, TransfertRNA Methyltransferaseselectron transport chainliver failuremitochondrial tRNANADH:ubiquinone oxidoreductaseoxidative phosphorylationposttranscriptional nucleotide modificationssuccinate dehydrogenasetissue-specific manifestationtranscriptomezebrafish

Identifiers

PMID41580081

DOI10.1016/j.jbc.2026.111168

PMCPMC12996652

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.