ArticleThe Journal of biological chemistry2026
Bacteriocin biophysics: From protein-protein interaction models to navigators of the bacterial cell envelope.
Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- NIR-Assisted Multimodal Strategies for Enhanced Antibacterial Therapy.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Bacteriocins in Veterinary Medicine: From Antibiotic Limitations to Targeted Solutions.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriocins are toxins deployed by bacteria to kill their competitors. Here, I reflect on my laboratory's work on protein bacteriocins and their immunity proteins from Gram-negative bacteria. We uncovered the structural and biophysical principles that underpin the 10-log stability range of protective immunity proteins for cytotoxic nuclease bacteriocins. We went on to elucidate how bacteriocins that kill Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae subvert outer membrane proteins and periplasmic energy transduction systems to drive their import. We leveraged our understanding of bacteriocin structure and function to probe the nature of the bacterial outer membrane. These studies revealed the outer membrane of E. coli to be an asymmetric proteolipid membrane, not an asymmetric lipid membrane as has been accepted dogma for the last 50 years. I contextualize the work with background on my career, collaborations, and academic leadership roles that influenced my development as a scientist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.