ArticleJournal of advanced research2026
Residential greenness, air pollution, and epilepsy: Insight in genetic susceptibility and life expectancy.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEpilepsy is one of the most common neurological disorders worldwide, yet evidence on its environmental determinants remains limited. Although a few studies have linked air pollution to epilepsy onset, the potential influence of residential greenness has not been investigated. Moreover, whether genetic susceptibility modifies these associations remains unclear.
objectivesWe aimed to examine the associations of residential greenness and air pollutants with incident epilepsy and to evaluate the modification effect of genetic susceptibility. We also assessed the relationship between environmental factors and life expectancy among people with epilepsy.
methodsResidential greenness was quantified using the normalized difference vegetation index (NDVI) for 437,526 UK Biobank participants. Air pollution levels were estimated using land-use regression models. Polygenic risk scores (PRS) were calculated to assess genetic susceptibility to epilepsy. These relationships were examined using Cox models. Causal mediation analysis was employed to estimate the mediation effects. Furthermore, we calculated population attributable risk (PAR%) and life expectancy.
resultsOver a median follow-up of 11.78 years, 2,448 incident epilepsy were identified. Each interquartile-range increase in greenness was associated with a 7-8% lower risk of epilepsy, whereas air pollution was associated with a 5-9% higher risk. Additive and multiplicative interactions were observed between greenness and PRS (all SIs < 1; P
conclusionsResidential greenness and air pollutants were associated with epilepsy incidence and progression. Interactions between greenness and genetic susceptibility were observed. Mitigating air pollution and enhancing greenness may provide substantial neurological health benefits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.