ArticleParkinsonism & related disorders2026
Temporal trends and risk factors of hospital readmission following deep brain stimulation for Parkinson disease.
Daniel G Di Luca, Adam de Havenon, Anagha Prabhune, Joel Perlmutter, Tamara Hershey, Scott A Norris
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In one paragraphArticle in Parkinsonism & related disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Daniel G Di LucaDepartment of Neurology, Washington University in St. Louis, MO, USA. Electronic address: dilucadaniel@wustl.edu.
Adam de HavenonDepartment of Neurology, Yale School of Medicine, CT, USA. Electronic address: adam.dehavenon@yale.edu.
Anagha PrabhuneDepartment of Neurology, Saint Louis University, MO, USA. Electronic address: anagha.prabhune@slucare.ssmhealth.com.
Joel PerlmutterDepartment of Neurology, Washington University in St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, MO, USA. Electronic address: perlmutterjoel@wustl.edu.
Tamara HersheyDepartment of Neurology, Washington University in St. Louis, MO, USA; Department of Psychiatry, Washington University in St. Louis, MO, USA. Electronic address: tammy@wustl.edu.
Scott A NorrisDepartment of Neurology, Washington University in St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, MO, USA. Electronic address: norriss@wustl.edu.
Funding
Medicinal Chemistry CoreU19NS110456 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ROBERT H MACH · 2019 to 2026
$44.1MProtein Aggregation and Neurotransmitter Deficits in Parkinson DiseaseR01NS097799 · NINDS · WASHINGTON UNIVERSITY · PI PAUL T KOTZBAUER · 2016 to 2026
$5.8MPET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3MParkinson Disease Clinical Subtypes: Validation, Clinical Utility, and Biological CorrelatesR01NS097437 · NINDS · WASHINGTON UNIVERSITY · PI MEGHAN C CAMPBELL · 2017 to 2026
$4.1MThe Role of Striatal Cholinergic Interneurons in DystoniaR01NS124789 · NINDS · WASHINGTON UNIVERSITY · PI Scott Allen Norris · 2022 to 2026
$3.0MPrecision-Mapping Functional Connectivity in Parkinson's DiseaseR01NS124738 · NINDS · WASHINGTON UNIVERSITY · PI MEGHAN C CAMPBELL, Caterina Gratton · 2023 to 2026
$2.4MInvestigations of Dementia in Parkinson DiseaseRF1NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2023 to 2023
$2.3MInvestigate neuroinflammation in the brain of PD using S1P1 radioligandsR01NS134586 · NINDS · WASHINGTON UNIVERSITY · PI JOEL Synes PERLMUTTER, Zhude Tu · 2024 to 2026
$1.8MEfficacy and Mechanisms of a Metacognitive Strategy Intervention for Parkinson disease-related Cognitive DeclineR01AG094871 · NIA · WASHINGTON UNIVERSITY · PI ERIN Foster · 2025 to 2026
$1.5MSing for Your Saunter: Using Self-Generated Rhythmic Cues to Enhance Gait in Parkinson'sR33AT010753 · NCCIH · WASHINGTON UNIVERSITY · PI EARHART, GAMMON M. · 2023 to 2025
$1.5MPrecision mapping of Parkinson's Disease pathophysiology in the Somato-Cognitive Action Network’s DBS targetsR01NS140256 · NINDS · WASHINGTON UNIVERSITY · PI Nico Dosenbach, Evan M. Gordon · 2025 to 2026
$1.2MTriangulating outcome assessments for blepharospasmR21TR005231 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETERSON, DAVID A · 2024 to 2024
$451kNCATS NIH HHS R21 TR005231NCCIH NIH HHS R33 AT010753NIA NIH HHS R01 AG094871NINDS NIH HHS R01 NS097437NINDS NIH HHS R01 NS097799NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS124738NINDS NIH HHS R01 NS124789NINDS NIH HHS R01 NS134586NINDS NIH HHS R01 NS140256NINDS NIH HHS RF1 NS075321NINDS NIH HHS U19 NS110456
6 · The paper itselfAbstract
backgroundRisk factors and long-term data on readmissions following deep brain stimulation (DBS) for Parkinson Disease (PD) remain unclear.
objectiveTo evaluate the temporal trend and risk factors associated with hospital readmission following DBS for PD.
methodsWe analyzed DBS procedures for PD in the National Readmissions Database (2016-2022). The association between demographic, clinical, and hospital factors with 90-day readmission following DBS was evaluated using a multivariable logistic and Cox regression models.
resultsAmong 7535 DBS surgeries, 8.1 % individuals were readmitted within 90 days. Higher Elixhauser-Comorbidity Index and complicated diabetes mellitus were associated with a higher risk of 90-day readmission (adjusted odds ratio 1.60, 95 % CI 1.06-2.41). Readmissions did not statistically significantly change between 2016 and 2022.
conclusionThe rate of non-elective readmissions following DBS for PD has not changed over time. A higher comorbidity index and complicated diabetes mellitus were identified as key risk factors.
Indexed as
Deep Brain StimulationParkinson DiseasePatient ReadmissionAgedComorbidityFemaleHumansMaleMiddle AgedRisk FactorsComorbidity indexDeep brain stimulationHospital readmissionOutcomes researchParkinson disease
Identifiers
PMID41579428
PMCPMC13355296
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