Evidence map›Paper›PMID 41579406›Full record

ArticleMolecular pharmaceutics2026

Prediction of Solvent Penetration Rate-Limited Release of Drug from Amorphous Solid Dispersion Discs of Various Geometries.

Shuaiqian Men, Yuly Chiang Yu, James E Polli

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shuaiqian MenDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States.
Yuly Chiang YuDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States.
James E PolliDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States.ORCID 0000-0002-5274-4314

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies have frequently shown that successful drug release from amorphous solid dispersions (ASDs) is highly dependent on polymer dissolution. Underpinning drug release from ASDs is a series of complex steps involving solvent penetration into the glassy core, gel formation and swelling, and colloid formation and release. The objective of this study was to predict ritonavir (RTV) and polymer release from ASDs of RTV and poly(vinylpyrrolidone-

Indexed as

RitonavirSolventsBulk DrugsChemistry, PharmaceuticalDrug LiberationPolymersPovidonePyrrolidinesSolubilityVinyl CompoundsBulk DrugsPolymerspoly(vinylpyrrolidone-co-vinyl-acetate)PovidonePyrrolidinesRitonavirSolventsVinyl Compoundsamorphous solid dispersionderivationdigital microscopePVPVArate-limiting stepritonavirwater penetration

Identifiers

PMID41579406
PMCPMC12958303

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.