SynthesisFEBS open bio2026
Meta-analysis fails to show any correlation between protein abundance and ubiquitination changes.
Synthesis in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Ubiquitination serves as a key regulatory mechanism in nearly all cellular processes, though it was originally identified as a post-translational modification that targets proteins for degradation. Accordingly, these two molecular events have since been tightly linked, and changes in protein abundance are frequently interpreted as indirect indicators of ubiquitination dynamics. Nevertheless, the relationship between protein abundance and ubiquitination has not been systematically examined across distinct biological systems. Here, we conducted a comprehensive meta-analysis to assess the correlation between protein abundance and ubiquitination levels determined by mass spectrometry in mammals, plants, and yeast. Quantitative proteomics and diGly-ubiquitin peptides data from 19 independent studies encompassing over 50 experimental conditions were analyzed. The findings indicate that alterations in protein abundance cannot reliably be used to infer ubiquitination events - and vice versa - highlighting the need for caution when interpreting proteomic data as a proxy for ubiquitin-mediated regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.