Evidence map›Paper›PMID 41579393›Full record

ArticleInternational journal of STD & AIDS2026

Ending Tuberculosis through prevention: Zimbabwe's PEPFAR Tuberculosis preventive treatment scale-up journey (2016-2024).

Talent Maphosa, Haddi Jatou Cham, Chiedza Marisa, Ruth Bulaya-Tembo, Amy Peterson, Mutsa Mhangara, Blessing Mushangwe, Gloria Mutukwa-Gonese, Batsirai Makunike-Chikwinya, Chidzewere Nzou and 9 more

Abstract read
In one paragraph

Article in International journal of STD & AIDS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Talent MaphosaDivision of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Harare, Zimbabwe.ORCID 0000-0001-9075-9616
Haddi Jatou ChamDivision of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Harare, Zimbabwe.
Chiedza MarisaDivision of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Harare, Zimbabwe.
Ruth Bulaya-TemboHealth Department, United States Agency for International Development, Harare, Zimbabwe.
Amy PetersonDivision of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Harare, Zimbabwe.
Mutsa MhangaraHealth Department, United States Agency for International Development, Harare, Zimbabwe.
Blessing MushangweHIV Care and Treatment Program, Zimbabwe Technical Assistance Training & Education Center for Health, Harare, Zimbabwe.
Gloria Mutukwa-GoneseHIV Care and Treatment Program, Zimbabwe Technical Assistance Training & Education Center for Health, Harare, Zimbabwe.
Batsirai Makunike-ChikwinyaHIV Care and Treatment Program, Zimbabwe Technical Assistance Training & Education Center for Health, Harare, Zimbabwe.
Chidzewere NzouHIV Care and Treatment Program, Zimbabwe Association of Church Related Hospitals, Harare, Zimbabwe.
Alex IngwaniHIV Care and Treatment Program, Zimbabwe Association of Church Related Hospitals, Harare, Zimbabwe.
Clorata GwanzuraAIDS and TB Program, Ministry of Health and Child Care, Harare, Zimbabwe.
Fungai KavengaAIDS and TB Program, Ministry of Health and Child Care, Harare, Zimbabwe.
Tsitsi Mutasa-ApolloAIDS and TB Program, Ministry of Health and Child Care, Harare, Zimbabwe.
Owen MugurungiAIDS and TB Program, Ministry of Health and Child Care, Harare, Zimbabwe.
Sarita ShahRollins School of Public Health and School of Medicine, Emory University, Atlanta, USA.
Macarthur CharlesDivision of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Atlanta, USA.
William CogginDivision of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Atlanta, USA.
Julia ErshovaDivision of Global HIV & TB, U.S. Centers for Disease Control and Prevention, Atlanta, USA.

Funding

Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2022 to 2026
$5.8M
Intramural CDC HHS CC999999NIAID NIH HHS P30 AI168386
6 · The paper itself

Abstract

BackgroundTuberculosis (TB) is the leading cause of death among people living with HIV (PLHIV). Globally in 2023, an estimated 161,000 PLHIV died of TB. TB preventive treatment (TPT) can reduce TB mortality yet scale up remains a challenge. We documented Zimbabwe's experience in scaling TPT among PLHIV.MethodologyWe analyzed routine aggregate data from the President Emergency Plan for AIDS Relief (PEPEFAR) database, Data for Accountability Transparency and Impact Monitoring (DATIM). We conducted a desk review of national guidelines, reports, training manuals, policy and strategic plans. Program reports were reviewed to understand scale up best practices, successes and challenges.ResultsTPT coverage (cumulative number completed TPT divided by PLHIV on ART) increased from <1% (144/950,235) in 2018 to 101% (1,040,460/1,029,583) in 2024, in PEPFAR supported health facilities. Adults had a higher TPT coverage of 102% (1,006,544/990,818) than children 87% (33,916/38,765). TPT completion (number started TPT divided number completing TPT) was significantly higher among adults, 99.2% compared to children, 97.9%, difference 1.2 percentage points (CI 0.98-1.50,

Indexed as

Antitubercular AgentsHIV InfectionsTuberculosisFemaleHumansProgram EvaluationZimbabweAntitubercular AgentsHIVpeople living with HIVpreventionTuberculosis

Identifiers

PMID41579393
PMCPMC13092141

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.