Evidence map›Paper›PMID 41579370›Full record

ArticleCell reports2026

Airway injury induces alveolar epithelial responses mediated by macrophages.

Irene G Wong, Margherita Paschini, Jillian Stark, Alan Baez Vazquez, VanNashlee Ya, Aaron L Moye, Susanna M Dang, Maria F Trovero, Emma L Thompson, Sidrah Ahmed and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Irene G WongHarvard University, Cambridge, MA 02138, USA; Stem Cell and Regenerative Biology Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Margherita PaschiniStem Cell and Regenerative Biology Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Jillian StarkStem Cell and Regenerative Biology Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard College, Cambridge, MA 02138, USA.
Alan Baez VazquezHarvard University, Cambridge, MA 02138, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
VanNashlee YaStem Cell and Regenerative Biology Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Aaron L MoyeStem Cell and Regenerative Biology Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Susanna M DangHarvard University, Cambridge, MA 02138, USA; Stem Cell and Regenerative Biology Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Maria F TroveroStem Cell and Regenerative Biology Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Emma L ThompsonStem Cell and Regenerative Biology Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Sidrah AhmedStem Cell and Regenerative Biology Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Fatima N ChaudhryDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Andrea ShehajStem Cell and Regenerative Biology Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Maral J RouhaniUCL Respiratory, Division of Medicine, University College London, London, UK.
Roderick BronsonRodent Histopathology Core, Harvard Medical School, Boston, MA 02115, USA.
Sam M JanesUCL Respiratory, Division of Medicine, University College London, London, UK.
Samuel P RowbothamStem Cell and Regenerative Biology Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Pediatric Surgical Research Laboratories, Mass. General Hospital, Boston, MA 02114, USA; Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
Jarod A ZeppDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ruth A FranklinDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Carla F KimStem Cell and Regenerative Biology Program, Division of Hematology/Oncology and Pulmonary & Respiratory Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: carla.kim@childrens.harvard.edu.

Funding

Microenvironmental control of progenitors in organ dysfunction and repairU01HL100402 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI KIM, CARLA F., SCADDEN, DAVID T · 2009 to 2015
$8.5M
Cell-cell interactions governing lung epithelial progenitor cellsR35HL150876 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Carla F. Kim · 2020 to 2026
$6.2M
Lung repair mechanisms mediated by the immune-fibroblast interfaceR35GM146835 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Jarod Zepp · 2022 to 2026
$2.2M
In Vivo and In Vitro Characterization of Bronchio-Alveolar Stem CellsR01HL090136 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI KIM, CARLA F. · 2007 to 2010
$1.9M
Macrophage-mediated regulation of inflammation and tissue repairR35GM150816 · NIGMS · HARVARD MEDICAL SCHOOL · PI Ruth A Franklin · 2023 to 2026
$1.9M
Signaling pathways in lung stem cell differentiationR01HL125821 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI KIM, CARLA F. · 2015 to 2018
$1.8M
Mechanisms of Thrombospondin-1 as a pulmonary vascular mediatorR01HL132266 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI KIM, CARLA F. · 2017 to 2020
$1.6M
Macrophage-Mediated Lung Repair Programs Following InjuryF31HL172650 · NHLBI · HARVARD UNIVERSITY · PI Alan Baez Vazquez · 2024 to 2026
$113k
Investigating the effects of airway injury on the alveolar compartment of the lung.F31HL159919 · NHLBI · HARVARD MEDICAL SCHOOL · PI WONG, IRENE GAR-LING · 2021 to 2022
$68k
NHLBI NIH HHS F31 HL159919NHLBI NIH HHS F31 HL172650NHLBI NIH HHS R01 HL090136NHLBI NIH HHS R01 HL125821NHLBI NIH HHS R01 HL132266NHLBI NIH HHS R35 HL150876NHLBI NIH HHS U01 HL100402NIGMS NIH HHS R35 GM146835NIGMS NIH HHS R35 GM150816
6 · The paper itself

Abstract

Airway injury activates local progenitors and stimulates cell-cell interactions to restore homeostasis, but it is unknown how distal niches are impacted. We utilized mouse models of airway-specific epithelial injury to examine secondary tissue-wide alveolar and immune responses. Single-cell transcriptomics and in vivo validation of mouse models of airway-specific epithelial injury revealed transient, tissue-wide proliferation of alveolar type 2 (AT2) progenitor cells after club cell-specific injury or ablation. Myeloid cells exhibited altered gene expression after club cell loss and were detectable in the bronchoalveolar lavage fluid. The AT2 cell proliferative response was reliant on alveolar macrophages (AMs) exhibiting an injury-induced gene expression program. Overall, these results demonstrate that acute airway damage can trigger myeloid-mediated lung alveolar responses that may contribute to disease susceptibility or dysfunction.

Indexed as

Alveolar Epithelial CellsMacrophages, AlveolarAnimalsCell ProliferationMiceMice, Inbred C57BLStem Cellsairway injuryalveolar macrophagesAT2club cellsCP: immunologylung stem cellsnaphthalene

Identifiers

PMID41579370
PMCPMC13090803

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.