Review in Physiological reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
7 authors.
Jorge A Masso-SilvaDivision of Pulmonary, Critical Care, Physiology and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, California, United States.ORCID 0000-0002-0739-4626
Alexia PerrymanDivision of Pulmonary, Critical Care, Physiology and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, California, United States.
Sophia KarandashovaDivision of Pulmonary, Critical Care, Physiology and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, California, United States.
Avnee Jaya KumarDivision of Pulmonary, Critical Care, Physiology and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, California, United States.ORCID 0000-0003-4421-6754
Laura BarnesDivision of Pulmonary, Critical Care, Physiology and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, California, United States.
Nikita KasaraneniDivision of Pulmonary, Critical Care, Physiology and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, California, United States.
Laura E Crotty AlexanderDivision of Pulmonary, Critical Care, Physiology and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, California, United States.ORCID 0000-0002-5091-2660
Funding
UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Electronic Cigarette Vapor Inhalation Adversely Affects Lung Cellular and Physiologic Function and Alters Systemic Inflammatory PathwaysR01HL137052 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CROTTY ALEXANDER, LAURA ELISE · 2017 to 2021
$2.3M
Developing a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander, Atul Malhotra · 2023 to 2026
$1.6M
Prospective Health Outcomes and Inflammatory Biomarkers Associated with e-Cigarette UseR01HL147326 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CASTALDI, PETER · 2019 to 2021
$1.5M
Convergence of Vitamin E, THC, Nicotine, Propylene Glycol and Glycerin Effects on Lung Inflammation When VapedK24HL155884 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander · 2022 to 2026
$609k
American Thoracic Society (ATS) ASPIREBLRD VA I01 BX004767BLRD VA I01 BX006447HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K24HL155884HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL137052HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL147326HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL166127HHS | NIH | National Institute of General Medical Sciences (NIGMS) K12GM068524NCIRD CDC HHS U01 IP000965NHLBI NIH HHS K24 HL155884NHLBI NIH HHS R01 HL137052NHLBI NIH HHS R01 HL147326NHLBI NIH HHS T32 HL166127NIGMS NIH HHS K12 GM068524Tobacco-Related Disease Research Program (TRDRP) T29IR0475Tobacco-Related Disease Research Program (TRDRP) T30IP0965Tobacco-Related Disease Research Program (TRDRP) T31IP1740Tobacco-Related Disease Research Program (TRDRP) T32KT4896Tobacco-Related Disease Research Program (TRDRP) T32SR5359Tobacco-Related Disease Research Program (TRDRP) T33FT6629Tobacco-Related Disease Research Program (TRDRP) T33IR6633UC | UCSD | School of Medicine, University of California, San Diego (SOM) Prebys Foundation's Recruit AwardU.S. Department of Veterans Affairs (VA) 1I01BX004767U.S. Department of Veterans Affairs (VA) 1I01BX006447
6 · The paper itself
Abstract
Although electronic cigarettes (e-cigarettes) have only been intensely studied since 2016, we have learned that the chemicals contained within e-cigarette aerosols (commonly called vapor) directly impact the function and phenotype of immune cells across the body (see Graphical Abstract). This review focuses on white blood cells (leukocytes) as well as immune functions of epithelial cells, which are critical for host defense. We also detail the modulation of inflammatory mediators in different compartments, such as saliva, blood, and airways, by e-cigarette vaping. Data are summarized across in vivo animal models, in vitro and ex vivo exposures of human and mouse cells, and human subjects, with an emphasis on human data. A multitude of changes in immune cells and inflammatory mediators in response to e-cigarette vapor exposure have been identified, and here we synthesize what is known and the likely effects on physiology across the body.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.