SynthesisJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2026
Left bundle branch area pacing in patients with and without interventricular septal hypertrophy: a systemic review and meta-analysis.
Synthesis in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConduction disease is common in patients with interventricular septal hypertrophy (IVSH). Left bundle branch area pacing (LBBAP) is a physiological pacing approach which preserves interventricular synchrony. There is limited data regarding the success rate and outcomes of LBBAP in patients with IVSH. In this study, we aimed to synthesize all available evidence on the feasibility and outcomes of LBBAP in patients with IVSH compared to those without IVSH.
methodsWe systematically reviewed bibliographic databases to identify studies published through August 2025. We included observational studies with available quantitative information on the success rate of LBBAP, lead penetration depth, paced QRS duration, and left ventricle activation time (LVAT) in patients with versus without IVSH. Estimates were combined using random-effects meta-analysis models and reported as risk ratios (RR) and 95% confidence intervals (CI).
resultsThree studies were included in the quantitative synthesis (49 IVSH and 701 non-IVSH patients). The pooled RR for success rate of LBBAP in IVSH patients compared to non-IVSH controls was 0.92 (95% CI = 0.82-1.04; P = 0.20). The pooled mean difference for lead penetration depth in IVSH patients compared to non-IVSH controls was 4.84 mm (95% CI = 3.86-5.82; P < 0.00001). The pooled mean difference for paced QRS duration in IVSH patients compared to non-IVSH controls was 6.66 ms (95% CI = 1.94 - 11.39; P = 0.006). The pooled mean difference for LVAT in IVSH patients compared to non-IVSH controls was 6.37 ms (95% CI = 3.07-9.67; P = 0.0002).
conclusionsCompared to non-IVSH patients, those with IVSH had comparable success rate of LBBAP with greater lead penetration depth, wider QRS duration, and longer LVAT.
Indexed as
Identifiers
41579252What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.