ArticleDermatology and therapy2026
Responses to Tetanus and Meningococcal Vaccines in Patients with Alopecia Areata Treated with Ritlecitinib.
Article in Dermatology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04006457 (A PHASE 3 OPEN-LABEL, MULTI-CENTER, LONG-TERM STUDY INVESTIGATING THE SAFETY AND EFFICACY OF PF-06651600 IN ADULT AND ADOLESCENT PARTICIPANTS WITH ALOPECIA AREATA), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A phase 3 open-label, multi-center, long-term study investigating the safety and efficacy of pf-06651600 in adult and adolescent participants with alopecia areata
Who cites it
1 citing paper in PubMed.
- JAK Inhibitors for Alopecia Areata: Approved Therapies, Efficacy, and Unanswered Questions.Drug design, development and therapy · 2026Review
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlopecia areata (AA) is an autoimmune disease characterized by nonscarring hair loss. Ritlecitinib, an oral JAK3/TEC family kinase inhibitor, inhibits cytokines that may be involved in humoral and cellular immunity and is approved to treat severe AA in patients aged ≥ 12 years. This sub-study of a phase 3 study evaluated primary immune responses to the meningococcal groups A, C, Y, and W-135 oligosaccharide diphtheria CRM
methodsAdult participants in the ALLEGRO-LT study (NCT04006457) receiving open-label ritlecitinib 50-mg once-daily for ≥ 6 months were eligible. Participants received a single-dose of 0.5-mL Tdap booster alone or in combination with a single dose of 0.5-mL MenACWY-CRM vaccine. Blood samples were collected at baseline pre-vaccination and 1 month post-vaccination.
resultsOverall, 17 participants received Tdap vaccination, of whom 13 also received meningococcal vaccination. At month 1 post-vaccination, 62.5% (10/16) of participants exhibited a tetanus booster response. All participants (16/16) achieved anti-tetanus antibody levels of 1.0 IU/mL and 0.1 IU/mL; 50% (8/16) showed a > fourfold increase from baseline. For the MenACWY-CRM vaccine, 20% (1/5) and 40% (2/5) of participants achieved human serum bactericidal activity titer for serogroup C ≥ 1:8 and ≥ 1:4, respectively. The geometric mean titer of antibodies for serogroup C increased from baseline (n = 12) to month 1 (n = 11). In total, three adverse events (AEs) occurred in three participants. No vaccine-related AEs, serious AEs, or permanent discontinuations due to AEs were reported.
conclusionsPrimary and secondary immune responses to the meningococcal and tetanus vaccines were observed in patients with AA during chronic ritlecitinib therapy, although the study was limited by the small sample size. The vaccines were well tolerated, no vaccine-related AEs were reported, and there was no exacerbation of underlying disease.
trial registrationClinicalTrials.gov identifier, NCT04006457.
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