Evidence map›Paper›PMID 41579194›Full record

Trial reportInternational orthopaedics2026

Molecular background behind lateral elbow pain reduction with Leukocyte-Rich and Leukocyte-Poor Platelet-Rich Plasma-randomized control trial and single-cell platelet analysis.

Joanna Wałecka, Paweł Bąkowski, Marta Jokiel, Rafał Trąbka, Monika Chaszczewska-Markowska, Daniel Ghete, Dorota Gurda-Woźna, Agnieszka Fedoruk-Wyszomirska, Przemyslaw Lubiatowski, Eliza Wyszko and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06854666 (Clinical and Morphological Evaluation Following Treatment of Lateral Epicondylar Tendinopathy with PRP or L-PRP,saline- Prospective Randomized Double Blinded Controlled Trial), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06854666 nacompletednot on this map

Clinical and Morphological Evaluation Following Treatment of Lateral Epicondylar Tendinopathy with PRP or L-PRP,saline- Prospective Randomized Double Blinded Controlled Trial

TypeinterventionalSponsorRehasport ClinicRan2017 to 2024Enrolled72ConditionsTennis Elbow, Lateral Epicondylitis, Lateral Epicondylitis (tennis Elbow), PRP InjectionArmseffectiveness of platelet-rich plasma (PRP) in treating lateral epicondylar tendinopathy (LET)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joanna WałeckaRehasport Clinic, Poznań, Poland. walecka.j@gmail.com.
Paweł BąkowskiInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Marta JokielDepartment of Traumatology, Orthopedics and Hand Surgery, Poznan University of Medical Sciences, Poznań, Poland.
Rafał TrąbkaDepartment of Rehabilitation, Faculty of Health Sciences, Jagiellonian University, Krakow, Poland.
Monika Chaszczewska-MarkowskaLaboratory of Clinical Immunogenetics and Pharmacogenetics, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Wrocław, Poland.
Daniel GheteBioscience Technology Facility, Department of Biology, University of York, York, United Kingdom.
Dorota Gurda-WoźnaInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Agnieszka Fedoruk-WyszomirskaInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Przemyslaw LubiatowskiRehasport Clinic, Poznań, Poland.
Eliza WyszkoInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Agata TyczewskaInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Kamilla Bąkowska-ŻywickaInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.

Funding

SECEC SECEC grant [Clinical and morphological evaluation following treatment of lateral epicondylar tendinopathy with PRP or L-PRP- prospective randomized trial]
6 · The paper itself

Abstract

purposeDegeneration at the common extensor origin leads to lateral elbow pain and reduced quality of life. We conducted a double-blind, randomized, placebo-controlled trial involving 71 patients treated with leukocyte-poor PRP (LP-PRP), leukocyte-rich PRP (LR-PRP), or saline.

methodsPRP content was analyzed using flow cytometry, confocal microscopy, and holotomography. Clinical outcomes (Visual Analogue Scale, Oxford Elbow Score) were assessed at baseline and at three, six, 12, 24, and 55 weeks.

resultsLR-PRP contained 3.8 × more leukocytes and 2.7 × fewer platelets than LP-PRP. Imaging revealed distinct platelet morphology and activation patterns between PRP types. The LP-PRP group showed significantly greater pain reduction at six weeks and improved elbow function from three to six weeks onward.

conclusionLP-PRP produced superior and longer-lasting clinical outcomes compared to LR-PRP and saline. CLINICALTRIALS: GOV: NCT06854666 (retrospectively registered on 2025-01-13).

Indexed as

Blood PlateletsLeukocytesPlatelet-Rich PlasmaTennis ElbowAdultDouble-Blind MethodFemaleFlow CytometryHumansMaleMiddle AgedPain MeasurementTreatment OutcomeHolotomographyOxford Elbow ScorePlatelet-rich plasmaTennis elbowVAS pain

Identifiers

PMID41579194

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.