ReviewNaunyn-Schmiedeberg's archives of pharmacology2026
A review on hypervirulent and multidrug-resistant Klebsiella pneumoniae: An emerging threat to human health.
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A dual-tier plasmid network model underpins the evolutionary success of pandemic Klebsiella pneumoniae ST11.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Klebsiella pneumoniae has a long history of causing infections as an opportunistic pathogen. There is an upsurge in infections caused by K. pneumoniae, mainly due to its two pathotypes, classical K. pneumoniae (cKP) and hypervirulent K. pneumoniae (hvKP). Various infections associated with these pathotypes include pneumonia, urinary tract infections, bloodstream infections, and pyogenic liver abscesses. This review provides an update on the pathogenicity, virulence factors, mechanisms of virulence, emergence and dissemination of multidrug resistance, as well as the convergence of virulence and resistance in K. pneumoniae, which is considered a significant threat to human health. The cKP infects only immunocompromised individuals, and these infections are mostly curable. However, hvKP can infect both healthy and immunocompromised individuals, and exhibits a strong defense against antibacterial therapy due to its hypermucoviscous characteristic. The increasing development of multidrug resistance among these strains poses a significant treatment challenge. Due to its enhanced pathogenicity, resistance against multiple antibacterial drugs, and capability for widespread transmission, multidrug-resistant hypervirulent K. pneumoniae (MDR-hvKP) has emerged as a global public health concern. The cKP may acquire virulence and resistance plasmids, resulting in MDR-cKP, which later transitions into MDR-hvKP. The hvKP becomes MDR-hvKP by acquiring resistance plasmids. Virulence plasmids are a characteristic feature of hvKP and are non-conjugative; however, these could be horizontally transferred with resistance plasmids. Additionally, virulence and resistance plasmids undergo recombination, resulting in hybrid MDR-hvKP plasmids aiding in the dissemination of virulence and resistance determinants. The convergence of virulence and resistance makes K. pneumoniae a very aggressive pathogen. The acquisition and recombination of virulence and resistance plasmids drive the emergence and global spread of MDR-hvKP, severely limiting therapeutic options. Understanding the genetic mechanisms underlying this convergence is essential for developing effective surveillance, infection control, and targeted therapeutic strategies to minimise the growing impact of MDR-hvKP infections.
Indexed as
Identifiers
41579175What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.