Evidence map›Paper›PMID 41579156›Full record

ArticleNeuroradiology2026

The diagnostic value of cortical high-flow sign combined with cystathionine on

Koji Yamashita, Moyoko Tomiyasu, Kazufumi Kikuchi, Daichi Momosaka, Masaoki Kusunoki, Daisuke Kuga, Ryusuke Hatae, Yutaka Fujioka, Ryosuke Otsuji, Osamu Togao and 2 more

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Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Koji YamashitaDepartment of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. yamashita.koji.659@m.kyushu-u.ac.jp.
Moyoko TomiyasuRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kazufumi KikuchiDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Daichi MomosakaDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masaoki KusunokiDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Daisuke KugaDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ryusuke HataeDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yutaka FujiokaDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ryosuke OtsujiDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Osamu TogaoDepartment of Radiology, Faculty of Medicine, Saga University, Saga, Japan.
Koji YoshimotoDepartment of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kousei IshigamiDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo leverage a combination of cortical high-flow sign on arterial spin labeling (ASL) and cystathionine measurement using MATERIALS AND

methodsWe implemented pseudo-continuous ASL technique (post-labeling delay = 2000 ms) using a 3.0-T MRI scanner. Relative perfusion maps were generated by subtracting paired labeled images from control images.

resultsThe cortical high-flow sign was identified more frequent in O_IDHm-codel (7/12, 58.3%) than in A_IDHm-noncodel (3/18, 16.7%; p = 0.018). The cystathionine levels in O_IDHm-codel (1.50 ± 0.63 mM) was significantly higher than in A_IDHm-noncodel (0.85 ± 0.24 mM; p = 0.001). The area under the curve for distinguishing O_IDHm-codel from A_IDHm-noncodel using the presence of cortical high-flow sign, cystathionine levels, and their combination was 0.708 (0.509-0.908), 0.750 (0.553-0.947), and 0.875 (0.737-1.000), respectively.

conclusionThe presence of cortical high-flow sign on ASL, along with elevated cystathionine levels measured by 1H-MRS, could differentiate O_IDHm-codel from A_IDHm-noncodel.

Indexed as

Brain NeoplasmsCystathionineGliomaIsocitrate DehydrogenaseAdultChromosomes, Human, Pair 1Chromosomes, Human, Pair 19FemaleHumansMagnetic Resonance SpectroscopyMaleMiddle AgedMutationPerfusion Magnetic Resonance ImagingSensitivity and SpecificitySpin LabelsCystathionineIsocitrate DehydrogenaseSpin LabelsAdult-type diffuse gliomaArterial spin labelingCortical high-flow signCystathionineMR spectroscopy

Identifiers

PMID41579156

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.