NanoBondy Reaction through NeissLock Anhydride Allows Covalent Immune Cell Decoration.

Lasya R Vankayala, Kish R Adoni, Sheryl Y T Lim, Tommy Dam, Omer Dushek, Konstantinos Thalassinos, Mark R Howarth

Abstract read

In one paragraph

Article in Bioconjugate chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lasya R VankayalaDepartment of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.

Kish R AdoniInstitute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, U.K.ORCID 0000-0001-7390-501X

Sheryl Y T LimDepartment of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.ORCID 0000-0002-2606-9220

Tommy DamSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K.

Omer DushekSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K.

Konstantinos ThalassinosInstitute of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, U.K.ORCID 0000-0001-5072-8428

Mark R HowarthDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.ORCID 0000-0001-8870-7147

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-surface conjugation has enormous therapeutic and research potential. Existing technologies for cell-surface modification are usually reversible, nonspecific, or rely on genetic editing of target cells. Here, we present the NanoBondy, a nanobody modified for covalent ligation to an unmodified protein target at the cell surface. The NanoBondy utilizes the 20 naturally occurring amino acids, harnessing NeissLock chemistry engineered from

Indexed as

AnhydridesLeukocyte Common AntigensNeisseria meningitidisHumansAnhydridesLeukocyte Common Antigens

Identifiers

PMID41578972

DOI10.1021/acs.bioconjchem.5c00519

PMCPMC12921663

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Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.