ArticleEpilepsia2026
Is posttraumatic stress disorder specific to drug-resistant epilepsy or a common feature of chronic disease? A comparative study with atrial fibrillation and type 1 diabetes.
Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePosttraumatic stress disorder (PTSD) is more prevalent in epilepsy than in the general population. However, it remains unclear whether this association is specific to epilepsy or a broader consequence of experiencing unpredictable acute episodes within chronic diseases. This study aimed to (1) compare PTSD prevalence and severity in patients with drug-resistant epilepsy (DRE) and patients with other chronic episodic diseases, namely, type 1 diabetes (T1D) and drug-resistant atrial fibrillation (AF); and (2) examine psychiatric comorbidities, emotion regulation, and quality of life across groups.
methodsA total of 122 patients (64 with DRE; 58 with chronic diseases: 30 with AF, 28 with T1D) completed questionnaires assessing PTSD symptoms, trauma exposure, anxiety, depression, dissociation, emotion regulation, and quality of life. Statistical analyses included χ
resultsPTSD was significantly more prevalent in the DRE group (34.94%) than in the chronic disease group (12.07%; χ SIGNIFICANCE: Our findings suggest that the psychiatric burden observed in DRE cannot be solely attributed to chronic episodic disease status. Instead, it may reflect the impact of early and repeated traumatic exposures and their interaction with the neurobiological underpinnings of epilepsy. The strong association between complex trauma, psychiatric comorbidities, and poor quality of life supports the hypothesis of psychoepileptogenesis and calls for integrated trauma-informed care in epilepsy management.
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