SynthesisMovement disorders : official journal of the Movement Disorder Society2026
Impact of Alcohol Intake on Parkinson's Disease Risk and Progression: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies.
Synthesis in Movement disorders : official journal of the Movement Disorder Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Alcohol Intake and Parkinson Symptoms Following Diagnosis.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Reply to: "Alcohol Intake and Parkinson's Symptoms Following Diagnosis".Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Preventing Parkinson's disease in the context of movement disorders: a narrative review of current evidence and future directions.Neurological research and practice · 2026Review
- Age at first drink below 19 years and all-cause mortality in Chinese older adults: a 10-year prospective cohort study.Frontiers in nutrition · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between alcohol consumption and Parkinson's disease (PD) risk remains unclear, whereas smoking has an inverse relationship with the disease. This study systematically reviewed and meta-analyzed 16 studies (2014-2024) from PubMed, Scopus, Web of Science, MEDLINE, and the Cochrane Library to assess the relationship between alcohol intake and PD risk, examining sex differences, dose-response patterns, smoking interactions, and genetic factors. Alcohol consumption was classified as low, moderate, or heavy, considering beverage type, sex, smoking status, and gene-environment interactions. Random-effects meta-analyses were used to evaluate sex-stratified and subtype-specific associations. PD progression, Mendelian randomization (MR), and gene-environment results were narratively synthesized. Sex-stratified analyses showed inverse associations between alcohol consumption and PD risk versus non-drinkers (lifetime relative risk [LRR] = -0.35 to -0.62), with significant effects in women and no association in low-level drinkers. Subtype analyses indicated protective effects for liquor (RR = -0.12) and wine (RR = -0.16), but not for low-level drinkers. Combined alcohol and smoking exposure produced the greatest PD risk reduction (LRR = -0.37), with pooled estimates confirming an inverse association (LRR = -0.20, I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.