Evidence map›Paper›PMID 41578653›Full record

Observational studyClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2026

Early Detection of Lower Adherence to Long-Term e-Diary Recording: A Checkpoint to Target Early Educational Intervention in Seasonal Allergic Rhinitis?

S Dramburg, C J Hernandez Toro, U Grittner, S Tripodi, S Arasi, A Acar Şahin, X Aggelidis, A Barbalace, A Bourgoin, B Bregu and 46 more

Abstract readMulticenter StudyObservational Study
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Observational study in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

56 authors.

S DramburgDepartment of Pediatric Respiratory Care, Immunology and Intensive Care Medicine, Charit-Universitätsmedizin Berlin, Berlin, Germany.
C J Hernandez ToroDepartment of Pediatric Respiratory Care, Immunology and Intensive Care Medicine, Charit-Universitätsmedizin Berlin, Berlin, Germany.
U GrittnerInstitute of Biometry and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
S TripodiPediatric Allergy Unit, Sandro Pertini Hospital, Rome, Italy.
S ArasiDepartment of Pediatric Respiratory Care, Immunology and Intensive Care Medicine, Charit-Universitätsmedizin Berlin, Berlin, Germany.
A Acar ŞahinDepartment of Biology, Faculty of Science, Ankara University, Ankara, Turkey.
X AggelidisAllergy Unit, 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, University Hospital 'Attikon', Athens, Greece.ORCID https://orcid.org/0000-0003-1715-3022
A BarbalaceDepartment of Pediatrics-Allergy Unit, University of Messina, Messina, Italy.
A BourgoinDepartment of Pneumonology and Allergy, La Timone Hospital, APHM, Aix-Marseille University, Marseille, France.
B BreguDepartment of Allergology and Clinical Immunology, UHC Mother Teresa, Medical University Tirana, Tirana, Albania.
M A BrighettiDepartment of Biology, Tor Vergata University, Rome, Italy.
E CaeiroMED- Mediterranean Institute for Agriculture, Environment and Development & CHANGE-Global Change and Sustainability Institute, Institute for Advanced Studies and Research, University of Évora, Évora, Portugal.
S Caglayan SozmenFenerbahce University, Istanbul, Turkey.
L CaminitiDepartment of Pediatrics-Allergy Unit, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0003-3054-5338
D CharpinDepartment of Pneumonology and Allergy, La Timone Hospital, APHM, Aix-Marseille University, Marseille, France.
M CoutoImmunoallergology, Hospital CUF Trindade, Porto, Portugal.
L DelgadoBasic and Clinical Immunology Unit, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal.
A Di Rienzo BusincoPediatric Allergy Unit, Sandro Pertini Hospital, Rome, Italy.
C DimierDepartment of Pneumonology and Allergy, La Timone Hospital, APHM, Aix-Marseille University, Marseille, France.
M V DimouAllergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital 'P&A Kyriakou', University of Athens, Athens, Greece.
J A FonsecaRISE-Health, Faculty of Medicine of the University of Porto, Porto, Portugal.
O GokselDepartment of Pulmonary Medicine, Division of Immunology, Allergy and Asthma, Faculty of Medicine, EgeSAM-Ege University Translational Pulmonary Research Center, Ege University, Izmir, Turkey.ORCID https://orcid.org/0000-0003-1121-9967
D HernandezDepartment of Allergy, Health Research Institute Hospital La Fe, Valencia, Spain.
T M HoffmannDepartment of Pediatric Respiratory Care, Immunology and Intensive Care Medicine, Charit-Universitätsmedizin Berlin, Berlin, Germany.
D T JangPediatric Allergy and Pneumology Unit, Children's Hospital La Fe, Health Research Institute La Fe, Valencia, Spain.
F KalpakliogluDepartment of Immunology and Allergic Diseases, Kırıkkale University School of Medicine, Kırıkkale, Turkey.
B LameDepartment of Allergology and Clinical Immunology, UHC Mother Teresa, Medical University Tirana, Tirana, Albania.
R LlusarPediatric Allergy and Pneumology Unit, Children's Hospital La Fe, Health Research Institute La Fe, Valencia, Spain.
M MakrisAllergy Unit, 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, University Hospital 'Attikon', Athens, Greece.
A MazonPediatric Allergy and Pneumology Unit, Children's Hospital La Fe, Health Research Institute La Fe, Valencia, Spain.
E MesonjesiDepartment of Allergology and Clinical Immunology, UHC Mother Teresa, Medical University Tirana, Tirana, Albania.
A NietoPediatric Allergy and Pneumology Unit, Children's Hospital La Fe, Health Research Institute La Fe, Valencia, Spain.
A ÖztürkDepartment of Pulmonary Medicine, Division of Allergy and Immunology, School of Medicine, Koç University, Istanbul, Turkey.
L PahusAix Marseille Univ, APHM, INSERM CIC 1409, INSERM U1263, INRA 1260 (C2VN), Marseille, France.
G PajnoDepartment of Pediatrics-Allergy Unit, University of Messina, Messina, Italy.
I PanasitiDepartment of Pediatrics-Allergy Unit, University of Messina, Messina, Italy.
N G PapadopoulosAllergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital 'P&A Kyriakou', University of Athens, Athens, Greece.
E PellegriniDepartment of Reggio Calabria, ARPA- Regional Agency for Environmental Protection, Calabria, Italy.
S PelosiTPS Production Srl, Rome, Italy.
A M PereiraRISE-Health, Faculty of Medicine of the University of Porto, Porto, Portugal.
M PereiraBasic and Clinical Immunology Unit, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal.
N M PinarDepartment of Biology, Faculty of Science, Ankara University, Ankara, Turkey.
E PotapovaDepartment of Pediatric Respiratory Care, Immunology and Intensive Care Medicine, Charit-Universitätsmedizin Berlin, Berlin, Germany.
A PriftanjiDepartment of Allergology and Clinical Immunology, UHC Mother Teresa, Medical University Tirana, Tirana, Albania.
F PsarrosAllergy Department, Athens Naval Hospital, Athens, Greece.
C SackesenDivision of Pediatric Allergy, Koç University School of Medicine, Istanbul, Turkey.
I SfikaPediatric Allergy Unit, Sandro Pertini Hospital, Rome, Italy.
J SuarezDepartment of Biology of Organisms and Systems, Area of Botany, University of Oviedo, Oviedo, Spain.
M ThibaudonRéseau National de Surveillance Aérobiologique, Brussieu, France.
A TravagliniDepartment of Biology, Tor Vergata University, Rome, Italy.ORCID https://orcid.org/0000-0002-4373-0105
U UguzDepartment of Biology, Faculty of Science, Ege University, Izmir, Turkey.
V VerdierDepartment of Pneumonology and Allergy, La Timone Hospital, APHM, Aix-Marseille University, Marseille, France.
V VillellaPediatric Allergy Unit, Sandro Pertini Hospital, Rome, Italy.
P XepapadakiAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
D YaziciCellular and Molecular Medicine, KUTTAM, Graduate School of Health Sciences, Koç University, Istanbul, Turkey.
P M MatricardiDepartment of Pediatric Respiratory Care, Immunology and Intensive Care Medicine, Charit-Universitätsmedizin Berlin, Berlin, Germany.

Funding

Euroimmun Medizinische Labordiagnostika 118583
6 · The paper itself

Abstract

backgroundDigital symptom monitoring via e-Diary apps can support the diagnosis and management of chronic diseases with trigger-induced exacerbations such as pollen allergies. Attrition is a major challenge for continuous e-Diary usage with an unsupervised approach.

objectiveTo investigate adherence to e-Diary reporting, its early determinants and predictors in a blended care setting among pollen allergic patients with heterogeneous cultural backgrounds.

methodsThe @IT.2020 observational multicenter study recruited patients with diagnosed seasonal allergic rhinitis from seven Southern European/Mediterranean countries. Baseline characteristics were investigated through questionnaires, skin prick tests and serum specific IgE measurements. The study doctors asked patients to record their allergy symptoms via e-Diary (AllergyMonitor, TPS) daily during the clinically relevant season of pollination and increased mould concentrations.

resultsAmong 815 patients (467 adults, 348 children), the average prescribed e-Diary recording period was 106 (SD 47.1) days, with an average completion rate of 75.2% (SD 21.2%). Children (≥ 10 years) filled 73.8% (95% CI 68.1-79.4) of prescribed days without parental support. We identified a stable 'higher' and a more variable 'lower' adherence cluster. Adherence was weakly associated with disease severity, but not with age, gender, country, education or digital literacy. Short-term (first 3 weeks) adherence was strongly associated with long-term adherence (partial R

conclusionIn a blended care setting, adherence to e-Diary compilation among pollen allergic patients is high, irrespective of age and cultural background. Early identification of lower adherence is possible and might inform early interventions to improve patient adherence.

Indexed as

Early Intervention, EducationalPatient ComplianceRhinitis, Allergic, SeasonalAdherence InterventionsAdolescentAdultChildFemaleHumansImmunoglobulin EMaleMiddle AgedSurveys and QuestionnairesYoung AdultImmunoglobulin Eadherenceallergic rhinitisallergy symptomschronic diseasese‐diarypatient educationpatient‐reported outcomesremote monitoringreporting behaviour

Identifiers

PMID41578653
PMCPMC13135879

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