Evidence map›Paper›PMID 41578425›Full record

ArticleMagnetic resonance in medicine2026

Fast, Robust T2-IVIM Quantitative MRI With Distortion and Motion-Corrected Multi-Echo EPI.

Liam Timms, Mustafa Utkur, Cemre Ariyurek, Miriam Hewlett, Sila Kurugol, Onur Afacan

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liam TimmsDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-2248-4045
Mustafa UtkurDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-2521-9151
Cemre AriyurekDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-1691-7097
Miriam HewlettDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-0653-855X
Sila KurugolDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5081-4569
Onur AfacanDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-2112-3205

Funding

Acquisition of a Siemens 3T MRI for Research ImagingS10OD025111 · OD · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2018 to 2018
$2.0M
Robust quantitative MR imaging markers of response to therapy in Crohn’s DiseaseR01DK125561 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI KURUGOL, SILA · 2021 to 2025
$2.0M
Motion and Distortion Robust Diffusion Weighted Imaging Sequences for Pediatric PatientsR01NS121657 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Onur Afacan · 2022 to 2026
$1.7M
Improved 3D EPI for Pre-Surgical Mapping of EpilepsyR01NS133228 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Onur Afacan · 2024 to 2026
$1.6M
NIDDK NIH HHS R01 DK125561NIH HHS R01DK125561NIH HHS R01NS121657NIH HHS R01NS133228NIH HHS S10 OD025111NIH HHS S10OD025111NINDS NIH HHS R01 NS121657NINDS NIH HHS R01 NS133228
6 · The paper itself

Abstract

purposeTo enable robust, motion- and distortion-corrected T2-IVIM parameter estimation within clinically feasible scan times.

methodsA single-shot, multi-echo spin-echo EPI sequence was used to acquire abdominal diffusion-weighted MRI with time-efficient sampling of b-value and TE pairs. The multi-echo acquisition enabled distortion correction using reverse phase-encoding between echoes. Motion and distortion correction were applied before fitting a joint T2-IVIM model across the b-value and TE dimensions to obtain TE-independent IVIM parameters and compartment-specific T2 estimates. For comparison, a previously established single-echo T2-IVIM protocol with longer scan times and a single-echo protocol matched to the multi-echo parameters were acquired. Uncertainty was evaluated with wild bootstrap error analysis.

resultsThe multi-echo approach enabled motion- and distortion-corrected T2-IVIM mapping in under 5 min, compared with 11-13 min for the prior minimal single-echo protocol or nearly 19 min when acquired as separate shots. The liver was selected as the target organ due to its marked sensitivity to

conclusionThe combination of multi-echo sequence design and artifact correction enabled stable fitting of the extended T2-IVIM model with improved liver coverage and less than half the scan time of prior protocols. These advances support broader clinical applicability of T2-IVIM imaging by reducing acquisition burden while enhancing artifact correction and parameter robustness.

Indexed as

Diffusion Magnetic Resonance ImagingLiverPhantoms, ImagingAbdomenArtifactsEcho-Planar ImagingHumansImage Processing, Computer-Assisted

Identifiers

PMID41578425
PMCPMC12958457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.