Evidence map›Paper›PMID 41578412›Full record

ReviewJournal of cellular and molecular medicine2026

SWI/SNF Chromatin Remodelling Complex in Hepatic Physiology: Mechanistic Insights Into Development, Homeostasis and Pathogenesis.

Rui Li, Bo Zhang, Xinyu Wei, Jiayin Yang, Yongjie Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rui LiDepartment of Liver Transplantation Center, Institute of Organ Transplantation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Bo ZhangDepartment of Liver Transplantation Center, Institute of Organ Transplantation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xinyu WeiDepartment of Liver Transplantation Center, Institute of Organ Transplantation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jiayin YangDepartment of Liver Transplantation Center, Institute of Organ Transplantation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yongjie ZhouDepartment of Liver Transplantation Center, Institute of Organ Transplantation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0001-8189-0495

Funding

1.3.5 project for disciplines of excellence from West China Hospital of Sichuan University ZYGD24002National Natural Science Foundation of China 82173255National Science and Technology Major Project 2023ZD0502400
6 · The paper itself

Abstract

The liver executes essential metabolic functions including energy homeostasis, lipid biosynthesis, cholesterol regulation and xenobiotic detoxification. While hepatocyte metabolic activity forms the foundation of these processes, their precise regulation is achieved through chromatin remodelling mechanisms, with the SWI/SNF complex emerging as a central epigenetic orchestrator. Accumulating evidence positions this ATP-dependent chromatin remodeler as a critical regulator of hepatic development, homeostatic maintenance and pathological transformation. Through nucleosome repositioning and histone-DNA interaction modulation, the SWI/SNF complex governs transcriptional programs controlling cellular proliferation, differentiation and metabolic adaptation. This review synthesises current understanding of SWI/SNF-mediated epigenetic regulation in hepatic biology and explores its therapeutic potential for liver disorders.

Indexed as

Chromatin Assembly and DisassemblyChromosomal Proteins, Non-HistoneHomeostasisLiverLiver DiseasesTranscription FactorsAnimalsEpigenesis, GeneticHumansChromosomal Proteins, Non-HistoneSWI-SNF-B chromatin-remodeling complexTranscription FactorsBRG1chromatin remodellingHCCliver diseasesSWI/SNF complex

Identifiers

PMID41578412
PMCPMC12830369

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.