Evidence map›Paper›PMID 41578402›Full record

ArticleActa neuropathologica communications2026

Absence of Ledgf in mouse brain affects the Kmt2a/b and polycomb balance, synaptic transmission and motor function.

Laura Debusschere, Eduard Bentea, Cecilia Iglesias-Herrero, Nicolas Peredo, Siska Van Belle, Nam Joo Van der Veken, Anna Barber-Janer, Dieter Plessers, Wouter Peelaerts, Wout Hannes and 4 more

Abstract read
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In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Laura DebusschereADVANTAGE, Department of Pharmacological and Pharmaceutical Sciences, KU Leuven, Leuven, Flanders, Belgium.
Eduard BenteaLaboratory for Neurobiology and Gene Therapy, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Flanders, Belgium.
Cecilia Iglesias-HerreroADVANTAGE, Department of Pharmacological and Pharmaceutical Sciences, KU Leuven, Leuven, Flanders, Belgium.
Nicolas PeredoCenter for Brain and Disease Research, VIB Bioimaging Core Leuven, VIB Technologies, Leuven, Belgium.
Siska Van BelleADVANTAGE, Department of Pharmacological and Pharmaceutical Sciences, KU Leuven, Leuven, Flanders, Belgium.
Nam Joo Van der VekenADVANTAGE, Department of Pharmacological and Pharmaceutical Sciences, KU Leuven, Leuven, Flanders, Belgium.
Anna Barber-JanerLaboratory for Neurobiology and Gene Therapy, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Flanders, Belgium.
Dieter PlessersADVANTAGE, Department of Pharmacological and Pharmaceutical Sciences, KU Leuven, Leuven, Flanders, Belgium.
Wouter PeelaertsADVANTAGE, Department of Pharmacological and Pharmaceutical Sciences, KU Leuven, Leuven, Flanders, Belgium.
Wout HannesADVANTAGE, Department of Pharmacological and Pharmaceutical Sciences, KU Leuven, Leuven, Flanders, Belgium.
Martine MichielsADVANTAGE, Department of Pharmacological and Pharmaceutical Sciences, KU Leuven, Leuven, Flanders, Belgium.
Chris Van den HauteLaboratory for Neurobiology and Gene Therapy, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Flanders, Belgium.
Veerle BaekelandtLaboratory for Neurobiology and Gene Therapy, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Flanders, Belgium.
Zeger DebyserADVANTAGE, Department of Pharmacological and Pharmaceutical Sciences, KU Leuven, Leuven, Flanders, Belgium. zeger.debyser@kuleuven.be.

Funding

Aligning Science Across Parkinson's ASAP-000458Fonds Wetenschappelijk Onderzoek Doctoral fellowship
6 · The paper itself

Abstract

Lens epithelium-derived growth factor (LEDGF), encoded by the Psip1 gene, exists in two splice variants, LEDGF/p75 and LEDGF/p52. Although little is known about its role in the brain, LEDGF has been proposed to play a role in neurogenesis. Since known LEDGF binding partners, such as PogZ, CDA7L, MLL1 and MeCP2 are implicated in neurological dysfunction, we investigated the role of LEDGF in mouse brain. We developed a conditional Psip1 knock-out (cKO) mouse model by crossbreeding Psip1

Indexed as

Adaptor Proteins, Signal TransducingBrainHistone-Lysine N-MethyltransferaseMotor ActivityMyeloid-Lymphoid Leukemia ProteinPolycomb-Group ProteinsSynaptic TransmissionTranscription FactorsAnimalsMaleMethyl-CpG-Binding Protein 2MiceMice, KnockoutNeuronsAdaptor Proteins, Signal TransducingHistone-Lysine N-MethyltransferaseKmt2a protein, mouseMecp2 protein, mouseMethyl-CpG-Binding Protein 2Myeloid-Lymphoid Leukemia ProteinPolycomb-Group ProteinsTranscription Factors

Identifiers

PMID41578402
PMCPMC12910792

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.