Evidence map›Paper›PMID 41578292›Full record

ArticleBMC biology2026

Chromatin-mediated mechanisms of hybrid fertility in F

Li Ren, Kai Yang, Yiyan Zeng, Ruyi Zhang, Ling Liu, Huiya Guan, Jinhui Zhang, Xiaohuan Han, Shaojun Liu

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In one paragraph

Article in BMC biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li Ren *Engineering Research Center of Polyploid Fish Reproduction and Breeding, College of Life Sciences, Ministry of Education, Hunan Normal University, Changsha, Hunan, 410081, China. rl@hunnu.edu.cn.
Kai Yang *Engineering Research Center of Polyploid Fish Reproduction and Breeding, College of Life Sciences, Ministry of Education, Hunan Normal University, Changsha, Hunan, 410081, China.
Yiyan ZengEngineering Research Center of Polyploid Fish Reproduction and Breeding, College of Life Sciences, Ministry of Education, Hunan Normal University, Changsha, Hunan, 410081, China.
Ruyi ZhangEngineering Research Center of Polyploid Fish Reproduction and Breeding, College of Life Sciences, Ministry of Education, Hunan Normal University, Changsha, Hunan, 410081, China.
Ling LiuEngineering Research Center of Polyploid Fish Reproduction and Breeding, College of Life Sciences, Ministry of Education, Hunan Normal University, Changsha, Hunan, 410081, China.
Huiya GuanEngineering Research Center of Polyploid Fish Reproduction and Breeding, College of Life Sciences, Ministry of Education, Hunan Normal University, Changsha, Hunan, 410081, China.
Jinhui ZhangEngineering Research Center of Polyploid Fish Reproduction and Breeding, College of Life Sciences, Ministry of Education, Hunan Normal University, Changsha, Hunan, 410081, China.
Xiaohuan HanEngineering Research Center of Polyploid Fish Reproduction and Breeding, College of Life Sciences, Ministry of Education, Hunan Normal University, Changsha, Hunan, 410081, China.
Shaojun LiuEngineering Research Center of Polyploid Fish Reproduction and Breeding, College of Life Sciences, Ministry of Education, Hunan Normal University, Changsha, Hunan, 410081, China. lsj@hunnu.edu.cn.

Funding

National Key Research and Development Program of China 2023YFD2401602National Natural Science Foundation of China 32293252National Natural Science Foundation of China 32341057
6 · The paper itself

Abstract

backgroundInterspecific hybridization is a fundamental evolutionary process, yet it often results in male sterility due to genomic incompatibilities and disrupted epigenetic regulation. While fertility variation among hybrids is increasingly acknowledged, the precise mechanisms linking these molecular disruptions to reproductive outcomes in vertebrates remain underexplored.

resultsTo address this, we investigated testicular chromatin dynamics and gene expression in 19 mature male F

conclusionsThese findings provide insights into the chromatin-mediated mechanisms underpinning reproductive barriers in vertebrate hybrids, contributing to a deeper understanding of evolutionary divergence and hybrid incompatibility.

Indexed as

ChromatinCyprinidaeFertilityHybridization, GeneticAnimalsMaleChromatinChromatin accessibilityHybrid fishMale fertilityMulti-omics

Identifiers

PMID41578292
PMCPMC12911191

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.