Trial reportNutrition journal2026
Preconception dietary patterns and time-to-conception in the high-income multi-country NiPPeR study.
Trial report in Nutrition journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02509988 (Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health "), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health "(NiPPeR)"
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Ultra-processed food consumption and risk of infertility in adults: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
backgroundDietary patterns rich in plant-based foods, fish, and healthier fats are reportedly beneficial for fertility, but forming generalizable recommendations has been hindered by the lack of studies examining dietary patterns and time-to-conception (TTC) in cohorts with different ethnicities across geographical regions. To study the association of preconception dietary patterns with TTC in the multi-country NiPPeR trial.
methodsThis study is a secondary analysis of data collected in the NiPPeR randomized controlled trial. Women planning to conceive, without known fertility impairment, were recruited from the community in the UK, Singapore, and New Zealand (NZ). Dietary intake was assessed at preconception prior randomization, and across-site (“pooled”) data-driven dietary patterns were derived (n = 1406). TTC, derived as the number of days between recruitment and the estimated date of achieving a clinical pregnancy, and the chance of achieving a clinical pregnancy within a year, expressed as hazard ratios (HR), were analyzed using Cox proportional hazards models adjusted for preconception body mass index, age and gravidity.
resultsTwo pooled dietary patterns were identified: “Vegetables, Fruits and Nuts” (VFN), and “Fried potatoes, Processed meat and Sweetened beverages” (FPS). Compared with the lowest quartile of VFN score, those in the highest quartile took a shorter time to conceive [Days till 20% conceived (95% CI): 73.0 (60.6, 91.5) vs 166.5 (120.0, 229.5)], and showed a higher chance of conception within a year [HR (95% CI): 2.15 (1.66, 2.78)]. This difference was most evident in Singapore, where the overall adherence to a VFN diet was substantially lower than in the UK and NZ [median (IQR) VFN score (expressed as standard deviation scores): Singapore -0.88 (-1.11, -0.57), UK 0.45 (0.07, 0.92), NZ 0.47 (-0.02, 0.90)]. There was no association between the FPS diet and TTC in the cohort.
conclusionConsuming a diet rich in vegetables, fruits and nuts may shorten TTC and improve the chances of conception, particularly in populations with low intakes of such foods. CLINICAL
trial registrationClinicalTrials.gov, identifier: NCT02509988, Universal Trial Number U1111-1171–8056. Registered on 16 July 2015.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.