Observational studyBMC surgery2026
Detection of Candida spp. from peritoneal swabs indicate worse outcome in patients with perforated peptic ulcer: revisiting a longstanding debate.
Observational study in BMC surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Fungal Identification and Empirical Antifungal Treatment in Critically Ill Patients with Secondary Peritonitis-A Retrospective Cohort Study.Antibiotics (Basel, Switzerland) · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to evaluate the outcome of patients with perforated peptic ulcer, stratified by detection of Candida spp. from peritoneal swabs.
methodsA retrospective, single-center, observational study was performed. All adult patients with perforated peptic ulcer who underwent surgical therapy were included. Candida spp. detection was defined as the result of culture incubation from peritoneal swabs at the index surgery. Its association with postoperative complications and in-hospital mortality was analyzed.
resultsA total of 187 adult patients were included. Intraperitoneal pathogens were detected by microbiological analysis in 96 patients (61.9%). Candida spp. were detected in 62 patients (39.4%), of whom 23 (37.7%) received antifungal therapy. Patients with peritoneal detection of Candida spp. had an increased in-hospital mortality (OR 5.80, 95% CI 1.96–16.97, p < 0.001), and an increased rate of Clavien-Dindo grade III or higher complications (OR 6.08, 95% CI 2.95–12.54, p < 0.001), suture dehiscence (p = 0.003), and longer hospital stays (p = 0.002). The multivariable analysis revealed that severe complications (OR: 8.83; 95% CI: 3.19–24.46; p < 0.001) and in-hospital mortality (OR: 4.81; 95% CI: 1.16–19.90; p = 0.030) were significantly more prevalent among patients with peritoneal detection of Candida spp.
conclusionIntraperitoneal presence of Candida spp. is associated with increased morbidity and mortality in patients with perforated peptic ulcer.
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