Evidence map›Paper›PMID 41578221›Full record

ArticleBMC psychiatry2026

Sick leave patterns before and after commencement of psychological therapy among individuals with common mental disorders: a register-based, quasi-experimental study.

Alexis E Cullen, Emma Pettersson, Elin Lindsäter, Heidi Taipale, Antti Tanskanen, Ellenor Mittendorfer-Rutz, Magnus Helgesson

Abstract read
In one paragraph

Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexis E CullenDivision of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. alexis.cullen@ki.se.
Emma PetterssonDivision of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Elin LindsäterAcademic Primary Care Center, Region Stockholm, Sweden.
Heidi TaipaleDivision of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Antti TanskanenDivision of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Ellenor Mittendorfer-RutzDivision of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Magnus HelgessonDivision of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPsychological therapies have been shown to reduce sickness absence (SA) among individuals with common mental disorders (CMDs) in clinical trials, but their real-world impact is unclear. To address these knowledge gaps, we compared the likelihood of receiving publicly-financed SA compensation among individuals with CMDs who received at least one session of systematic psychological therapy in primary care and individuals with CMDs who did not receive these treatments.

methodsPrimary healthcare registers were used to identify individuals with CMDs in Region Stockholm who had received psychological therapies (N = 12,167) and untreated controls (N = 40,517). SA was measured at six-monthly intervals in the two years before and after treatment commencement. Crude and inverse probability weighted (IPW) generalised estimating equation (GEE) models were used to compare the likelihood of having > 14 net SA days (primary outcome) and > 30 and > 90 days (secondary outcomes) at each six-month interval to the period preceding treatment commencement (t0). Crude and IPW models were performed in the treated and control groups separately, with effects at each time-point compared via the ratio of odds ratios (ROR).

resultsIn the crude model, the treated group showed significantly greater reductions in the likelihood of having > 14 net SA days at t12, t18, and t24 compared to the control group (ROR: 0.82, 0.80, and 0.79, respectively). However, in the IPW models, the likelihood of receiving > 14 net SA days at t6 relative to t0 was significantly higher in the treated group (ROR: 1.33, 95% CI: 1.25–1.40) with no group differences at t12, t18, or t24. Moreover, the treated group fared significantly worse than the control group in IPW models examining > 30 and > 90 net SA days. In sensitivity analyses, individuals receiving 1–2 sessions showed a greater reduction in the likelihood of having the primary outcome relative to the control group at t12, t18, and t24, whilst those receiving greater doses of psychological therapy (6–12 and > 12 sessions) had a significantly higher likelihood of SA at these timepoints.

conclusionsOur findings tentatively suggest that psychological therapies delivered in primary care are not associated with a reduction in the likelihood of receiving sick leave in people with CMDs. However, due to the possibility of unmeasured confounders, our findings cannot support causal inferences. Further studies in real-world settings are needed to investigate whether treatment-related factors (e.g., therapeutic focus, quality, and fidelity) modify the effect of primary-care delivered psychological therapies on SA outcomes among people with CMDs. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Mental DisordersPsychotherapySick LeaveAdultFemaleHumansMaleMiddle AgedPrimary Health CareRegistriesSwedenAnxietyDepressionGeneral practicePsychotherapyStress-related disordersWork disability

Identifiers

PMID41578221
PMCPMC12849155

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.