Observational studyBMC geriatrics2026
Transbronchial lung cryobiopsy: a safe and effective technique in the diagnosis of interstitial lung disease in the older people.
Observational study in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Cryobiopsy at the dawn of fibrosis: unlocking early diagnosis and therapeutic windows.Frontiers in medicine · 2026Review
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivePatients presenting with interstitial lung disease (ILD) are getting older. In the older people, although idiopathic pulmonary fibrosis (IPF) is the most common ILD, the rate of unclassifiable ILD remains high after multidisciplinary discussion (MDD). One explicative factor could be the less frequent use of surgical lung biopsy (SLB) in this population because of its associated risks. Transbronchial lung cryobiopsy (TBLC) is a particularly interesting alternative to SLB in the diagnostic approach of ILD in older people subjects. Our objective was to assess the safety and diagnostic yield of TBLC in older people, as compared to younger patients.
methodsWe conducted a retrospective observational study in patients with ILD who underwent TBLC from 2015 to 2023. Individuals were defined as "older people" if they were older than or equal to 75 years.
resultsOut of 110 patients, 26 were classified as older people, with a median age of 78 years (IQR 76-79). In the whole cohort, the most represented HRCT pattern was "indeterminate" (27%). The rate of severe TBLC complications was 8% in the older people and 12% in the non-older people (p = 0.73). The diagnostic yield of TLBC was 85% in the older people and 79% in the non-older people (p = 0.50). In the older people group, the most common diagnoses after MDD were fibrotic hypersensitivity pneumonitis (31%) and IPF (31%).
conclusionIn ILD workup, the benefit/risk ratio of TBLC seems to be favorable in the older people, encouraging it to be proposed first in selected patients when clinical features are not appropriate for IPF.
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