Evidence map›Paper›PMID 41578087›Full record

ArticleNature plants2026

Creating a new oilseed crop, pennycress, by combining key domestication traits using CRISPR genome editing.

Barsanti Gautam, Brice A Jarvis, Maliheh Esfahanian, Michaela McGinn, Dalton Williams, Shengjun Liu, Mary E Phippen, Nicholas J Heller, Tad L Wesley, Winthrop B Phippen and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Barsanti GautamSchool of Biological Sciences, Illinois State University, Normal, IL, USA.ORCID 0009-0006-0949-8927
Brice A JarvisSchool of Biological Sciences, Illinois State University, Normal, IL, USA.
Maliheh EsfahanianSchool of Biological Sciences, Illinois State University, Normal, IL, USA.
Michaela McGinnSchool of Biological Sciences, Illinois State University, Normal, IL, USA.
Dalton WilliamsSchool of Biological Sciences, Illinois State University, Normal, IL, USA.
Shengjun LiuCoverCress Inc., St. Louis, MO, USA.
Mary E PhippenSchool of Agriculture, Western Illinois University, Macomb, IL, USA.ORCID 0009-0009-5674-6251
Nicholas J HellerSchool of Biological Sciences, Illinois State University, Normal, IL, USA.ORCID 0000-0001-6851-2481
Tad L WesleySchool of Agriculture, Western Illinois University, Macomb, IL, USA.
Winthrop B PhippenSchool of Agriculture, Western Illinois University, Macomb, IL, USA.ORCID 0009-0009-7437-5271
Tim UlmasovCoverCress Inc., St. Louis, MO, USA.
M David MarksDepartment of Agronomy and Plant Genetics, University of Minnesota, St. Paul, MN, USA.
Ratan ChopraCoverCress Inc., St. Louis, MO, USA.
John C SedbrookSchool of Biological Sciences, Illinois State University, Normal, IL, USA. jcsedbr@ilstu.edu.ORCID 0000-0002-4930-1627

Funding

DOE | SC | Biological and Environmental Research (BER) DE-SC0021286United States Department of Agriculture | National Institute of Food and Agriculture (NIFA) 2018-67009-27374United States Department of Agriculture | National Institute of Food and Agriculture (NIFA) 2019-69012-29851
6 · The paper itself

Abstract

Considerable off-season farmland lies fallow because few crops can profitably fit between primary crops. As a remedy, we performed de novo domestication of the freeze-tolerant, rapid-cycling wild brassica Thlaspi arvense L. (field pennycress), identifying and stacking CRISPR-Cas9-induced mutations that have minimal impacts on seed yields. High-yielding varieties were created with seed compositions such as 'double-low' canola (low erucic acid and reduced glucosinolate) and reduced seed fibre content. Seed glucosinolate content was reduced by 75% by combining mutations in R2R3-MYB (MYB28/HAG1) and basic helix-loop-helix MYC (MYC3) transcription factors. Pennycress weediness was greatly reduced by knockout of the basic helix-loop-helix transcription factor TRANSPARENT TESTA8 (TT8), which lowered seed dormancy and seed coat protections, thereby mitigating re-emergence in fields. Domesticated pennycress offers farmers a low-carbon-intensity intermediate crop that fits between two full-season summer crops, resulting in three cash crops in 2 years, conferring cover-crop-like ecosystem benefits while producing grain for renewable fuels and enhanced food security.

Indexed as

BrassicaCrops, AgriculturalDomesticationGene EditingCRISPR-Cas SystemsSeeds

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.