Evidence map›Paper›PMID 41578080›Full record

ArticleEuropean radiology2026

Added value of multiparametric MRI combining dynamic contrast-enhanced and diffusion-weighted imaging for determining thyroid-associated ophthalmopathy activity.

Xiong-Ying Pu, Ying Wan, Huan-Huan Chen, Jin-Ling Lu, Jiang Zhou, Fei-Yun Wu, Hao Hu, Xiao-Quan Xu

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Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xiong-Ying Pu *Department of Radiology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Ying Wan *Department of Radiology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Huan-Huan Chen *Department of Endocrinology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Jin-Ling LuDepartment of Radiology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Jiang ZhouDepartment of Radiology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Fei-Yun WuDepartment of Radiology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Hao HuDepartment of Radiology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China. haohu_njmu@163.com.
Xiao-Quan XuDepartment of Radiology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China. xiaoquanxu_1987@163.com.ORCID http://orcid.org/0000-0001-5493-5256

Funding

Jiangsu Province Capability Improvement Project through Science, Technology and Education JSDW202243Medical Research Project of Jiangsu Provincial Health Commission MQ2024050
6 · The paper itself

Abstract

objectiveTo evaluate the performance of model-based dynamic contrast-enhanced (DCE)-MRI and diffusion-weighted imaging (DWI) in determining the disease activity of thyroid-associated ophthalmopathy (TAO), and to establish their additional value to fat-suppressed T2-weighted imaging (FS-T2WI) for staging TAO. MATERIALS AND

methodsSeventy-two patients with TAO (48 active, 96 eyes; 24 inactive, 48 eyes) were prospectively enrolled. DCE-MRI, DWI and FS-T2WI were scanned for pre-treatment evaluation. Simplified histogram parameters (min, mean, max) of DCE-MRI-derived K

resultsActive TAO patients showed significantly higher mean and maximum V

conclusionDCE-MRI and DWI could determine the disease activity of TAO and provide additional value to FS-T2WI in staging TAO. KEY POINTS: Question Fat-suppressed T2-weighted imaging was the most commonly used imaging technique for determining the disease activity of thyroid-associated ophthalmopathy; however, its performance needs to be improved. Findings Dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging could provide added value to fat-suppressed T2-weighted imaging for determining the clinical activity of thyroid-associated ophthalmopathy. Clinical relevance Dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging can provide information about tissue permeability and water molecule diffusion of extraocular muscles in patients with thyroid-associated ophthalmopathy (TAO), and therefore provide additional value to fat-suppressed T2-weighted imaging in staging TAO.

Indexed as

Diffusion Magnetic Resonance ImagingGraves OphthalmopathyMultiparametric Magnetic Resonance ImagingAdultAgedContrast MediaDynamic Contrast Enhanced Magnetic Resonance ImagingFemaleHumansMaleMiddle AgedProspective StudiesReproducibility of ResultsROC CurveSensitivity and SpecificityContrast MediaDiffusion-weighted imagingDisease activityDynamic contrast-enhancedMagnetic resonance imagingThyroid-associated ophthalmopathy

Identifiers

PMID41578080

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.