Evidence map›Paper›PMID 41578032›Full record

ArticleNature biomedical engineering2026

Human gastric multi-regional assembloids for functional parietal maturation and patient-specific modelling of antral foveolar hyperplasia.

Brendan C Jones, Giada Benedetti, Giuseppe Calà, Ramin Amiri, Lucinda Tullie, Roberto Lutman, Jahangir Sufi, Lucy Holland, Daniyal J Jafree, Monika Balys and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Brendan C Jones *Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-2637-8859
Giada Benedetti *Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-6852-9993
Giuseppe CalàStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0003-2297-700X
Ramin AmiriDepartment of Civil, Chemical, Environmental and Materials Engineering, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-2455-0707
Lucinda TullieStem Cell and Cancer Biology Lab, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0001-5679-7504
Roberto LutmanStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London, UK.
Jahangir SufiCell Communication Lab, Department of Oncology, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0002-4563-5531
Lucy HollandStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London, UK.
Daniyal J JafreeDevelopmental Biology and Cancer Research and Teaching Department, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0001-8235-0394
Monika BalysDepartment of Histopathology, Great Ormond Street Hospital, London, UK.
Glenn AndersonDepartment of Histopathology, Great Ormond Street Hospital, London, UK.
Ian C SimcockNational Institute for Health and Care Research Great Ormond Street Hospital Biomedical Research Centre, London, UK.ORCID http://orcid.org/0000-0002-5619-0785
Owen J ArthursNational Institute for Health and Care Research Great Ormond Street Hospital Biomedical Research Centre, London, UK.ORCID http://orcid.org/0000-0003-1213-3516
Simon EatonStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0003-0892-9204
Nicola ElvassoreVeneto Institute of Molecular Medicine, Padua, Italy.ORCID http://orcid.org/0000-0002-7029-6287
Vivian Sw LiStem Cell and Cancer Biology Lab, The Francis Crick Institute, London, UK.
Christopher J TapeCell Communication Lab, Department of Oncology, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0003-4712-2737
Kelsey Dj JonesDepartment of Paediatric Gastroenterology and Nutrition, Great Ormond Street Hospital, London, UK.
Camilla LuniDepartment of Civil, Chemical, Environmental and Materials Engineering, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-1211-9629
Giovanni Giuseppe GiobbeStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London, UK. g.giobbe@ucl.ac.uk.ORCID http://orcid.org/0000-0001-6958-7303
Paolo De CoppiStem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College London, London, UK. p.decoppi@ucl.ac.uk.ORCID http://orcid.org/0000-0002-1659-0207

Funding

Great Ormond Street Hospital Charity (GOSH) VS2606Oak Foundation W1095/OCAY-14-191Rosetrees Trust Seedcorn2025\100314
6 · The paper itself

Abstract

Patient-derived human organoids have the capacity to self-organize into more complex structures. However, to what extent gastric organoids can recapitulate differentiated cell types and mucosal functions remains unexplored. Here we report on how region-specific gastric organoids can self-assemble into complex multi-regional assembloids. These assembloids show increased complexity and cross-communication between different gastric regions, allowing for the emergence of the elusive parietal cell type that is responsible for the production of gastric acid and shows a functional response to drugs targeting the H

Identifiers

PMID41578032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.