ArticleScientific reports2026
Comparative prognostic value of high-sensitivity cardiac troponin T and NT-proBNP for 30-day mortality in non-cardiac critically ill patients.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Mitochondrial Dysregulation and Molecular Signaling in Systemic Sclerosis Cardiac Disease: An Integrative Echocardiographic, Microvascular, and Biomarker Review.International journal of molecular sciences · 2026Review
- Use of Natriuretic Peptides in Critically Ill Patients: A Narrative Review.Journal of clinical medicine · 2026Review
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14 authors.
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Abstract
High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are organ-specific biomarkers reflecting myocardial injury and cardiac biomechanical stress, respectively. Yet, neither is disease-specific, and both are frequently elevated in critically ill patients even in the absence of acute cardiac disease. This lack of specificity complicates their interpretation, and their relative prognostic importance remains uncertain. We retrospectively analyzed 827 adults admitted to ICU, excluding acute cardiac admissions and compared the prognostic utility of hs-cTnT and NT-proBNP measured at ICU admission for predicting 30-day mortality in non-cardiac critically ill patients. Non-survivors had higher hs-cTnT (67.2 vs. 37.7 ng/L; p < 0.001) and NT-proBNP (2340.5 vs. 1087.0 pg/mL; p < 0.001). In multivariable Cox models, only hs-cTnT remained independently predictive (highest vs. lowest hs-cTnT quartile: HR 1.44, 95% CI 1.05-1.96, p = 0.022). Adding hs-cTnT significantly improved the clinical base model (ΔLR χ
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