Evidence map›Paper›PMID 41577989›Full record

ArticleScientific reports2026

Synergistic therapeutic impact of dichloroacetate nanoparticles and doxorubicin in modulating pyruvate dehydrogenase kinase in breast carcinoma model.

Maha M Salem, Amira T Khattab, Doha M Beltagy, Mai M El-Keiy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maha M SalemBiochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31257, Egypt. maha_salem@science.tanta.edu.eg.ORCID http://orcid.org/0000-0002-9108-6932
Amira T KhattabBiochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31257, Egypt.
Doha M BeltagyBiochemistry Department, Faculty of Science, Damanhour University, Damnhour, 22514, Egypt.
Mai M El-KeiyBiochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31257, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is treated with chemotherapies causing severe organ side effects. Increased pyruvate dehydrogenase kinase (PDK) enzymes in cancer cell metabolism lead to tumor resistance. This study examined dichloroacetate nanoparticles (DCA-PNPs)/doxorubicin (Dox) impact on PDK enzymes in Ehrlich ascites carcinoma (EAC) cells. DCA-PNPs were synthesized using poly D, L-lactic-co-glycolide, polyvinyl alcohol, and characterized by encapsulation efficiency, drug-loading capacity, spectroscopy, and microscopy. Molecular docking and ADMET analysis were conducted. Seventy female CD1 mice were divided into 10 groups (n = 7). (Gp1) was normal negative control. Gp2 to Gp4 received DCA (50 mg/kg), DCA-PNPs (50 mg/kg), and Dox (0.2 mg/kg), intraperitoneal (i.p.) injection. Gp5 to Gp10 were inoculated with EAC cells 0.5 × 10

Indexed as

Breast NeoplasmsDichloroacetic AcidDoxorubicinNanoparticlesPyruvate Dehydrogenase Acetyl-Transferring KinaseAnimalsApoptosisCarcinoma, Ehrlich TumorCell Line, TumorDrug SynergismFemaleMiceMolecular Docking SimulationDichloroacetic AcidDoxorubicinPyruvate Dehydrogenase Acetyl-Transferring KinaseBreast cancerCancer metabolismDichloroacetate nanoparticlesMitochondrial membranePyruvate dehydrogenase kinase

Identifiers

PMID41577989
PMCPMC12835023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.